CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Aromatherapy

Aromatherapy uses plant materials and aromatic plant oils, including essential oils, and other aroma compounds for improving psychological or physical well-being.

It can be offered as a complementary therapy or as a form of alternative medicine. Complementary therapy can be offered alongside standard treatment, with alternative medicine offered instead of conventional, evidence-based treatments.

Aromatherapists, who specialize in the practice of aromatherapy, utilize blends of therapeutic essential oils that can be issued through topical application, massage, inhalation or water immersion to stimulate a desired response.

There is no good medical evidence that aromatherapy can either prevent or cure any disease, but it might help improve general well-being.

  • The Effectiveness of Aromatherapy for Depressive Symptoms: A Systematic Review📎

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    Abstract Title:

    The Effectiveness of Aromatherapy for Depressive Symptoms: A Systematic Review.

    Abstract Source:

    Evid Based Complement Alternat Med. 2017 ;2017:5869315. Epub 2017 Jan 4. PMID: 28133489

    Abstract Author(s):

    Dalinda Isabel Sánchez-Vidaña, Shirley Pui-Ching Ngai, Wanjia He, Jason Ka-Wing Chow, Benson Wui-Man Lau, Hector Wing-Hong Tsang

    Article Affiliation:

    Dalinda Isabel Sánchez-Vidaña

    Abstract:

    Background. Depression is one of the greatest health concerns affecting 350 million people globally. Aromatherapy is a popular CAM intervention chosen by people with depression. Due to the growing popularity of aromatherapy for alleviating depressive symptoms, in-depth evaluation of the evidence-based clinical efficacy of aromatherapy is urgently needed. Purpose. This systematic review aims to provide an analysis of the clinical evidence on the efficacy of aromatherapy for depressive symptoms on any type of patients. Methods. A systematic database search was carried out using predefined search terms in 5 databases: AMED, CINHAL, CCRCT, MEDLINE, and PsycINFO. Outcome measures included scales measuring depressive symptoms levels. Results. Twelve randomized controlled trials were included and two administration methods for the aromatherapy intervention including inhaled aromatherapy (5 studies) and massage aromatherapy (7 studies) were identified. Seven studies showed improvement in depressive symptoms. Limitations. The quality of half of the studies included is low, and the administration protocols among the studies varied considerably. Different assessment tools were also employed among the studies. Conclusions. Aromatherapy showed potential to be used as an effective therapeutic option for the relief of depressive symptoms in a wide variety of subjects. Particularly, aromatherapy massage showed to have more beneficial effects than inhalation aromatherapy.

  • The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis📎

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    Abstract Title:

    The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis.

    Abstract Source:

    Pain Res Treat. 2016 ;2016:8158693. Epub 2016 Dec 14. PMID: 28070420

    Abstract Author(s):

    Shaheen E Lakhan, Heather Sheafer, Deborah Tepper

    Article Affiliation:

    Shaheen E Lakhan

    Abstract:

    Background. Aromatherapy refers to the medicinal or therapeutic use of essential oils absorbed through the skin or olfactory system. Recent literature has examined the effectiveness of aromatherapy in treating pain. Methods. 12 studies examining the use of aromatherapy for pain management were identified through an electronic database search. A meta-analysis was performed to determine the effects of aromatherapy on pain. Results. There is a significant positive effect of aromatherapy (compared to placebo or treatments as usual controls) in reducing pain reported on a visual analog scale (SMD = -1.18, 95% CI: -1.33, -1.03; p<0.0001). Secondary analyses found that aromatherapy is more consistent for treating nociceptive (SMD = -1.57, 95% CI: -1.76, -1.39, p<0.0001) and acute pain (SMD = -1.58, 95% CI: -1.75, -1.40, p<0.0001) than inflammatory (SMD = -0.53, 95% CI: -0.77, -0.29, p<0.0001) and chronic pain (SMD = -0.22, 95% CI: -0.49, 0.05, p = 0.001), respectively. Based on the available research, aromatherapy is most effective in treating postoperative pain (SMD = -1.79, 95% CI: -2.08, -1.51, p<0.0001) and obstetrical and gynecological pain (SMD = -1.14, 95% CI: -2.10, -0.19, p<0.0001). Conclusion. The findings of this study indicate that aromatherapy can successfully treat pain when combined with conventional treatments.

  • The effectiveness of aromatherapy massage using lavender oil as a treatment for infantile colic.

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    Abstract Title:

    The effectiveness of aromatherapy massage using lavender oil as a treatment for infantile colic.

    Abstract Source:

    Int J Nurs Pract. 2012 Apr ;18(2):164-9. PMID: 22435980

    Abstract Author(s):

    Bengü Cetinkaya, Zümrüt Başbakkal

    Article Affiliation:

    Assistant Professor, Department of Pediatric Nursing, Pamukkale University Denizli School of Health, Denizli, Turkey Professor, Department of Pediatric Nursing, Ege University Faculty of Nursing,İzmir, Turkey.

    Abstract:

    Çetinkaya B, Başbakkal Z. International Journal of Nursing Practice, 2012; 18: 164-169 The effectiveness of aromatherapy massage using lavender oil as a treatment for infantile colic The aim of this paper was to investigate the effect of aromatherapy massage using lavender oil as a possible treatment for this condition. This research was carried out on a group of 40 infants between 2 and 6 weeks of age with a gestational age of 38-42 weeks and normal development and growth. All the infants weighed between 2500 and 4000 g at birth and all exhibited the signs of colic. Infants in the treatment group received abdominal massage by their mothers using lavender oil, while those in the control group were not subject to an intervention. The infants in both control and treatment groups were monitored once a week by the researchers, in total five times. The effect of the massage was measured in terms of changes in the length of time the infants cried per week. The use of aromatherapy massage using lavender oil was found to be effective in reducing the symptoms of colic.

  • The effectiveness of relaxation acupoint stimulation and acupressure with aromatic lavender essential oil for non-specific low back pain in Hong Kong: a randomised controlled trial.

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    Abstract Title:

    The effectiveness of relaxation acupoint stimulation and acupressure with aromatic lavender essential oil for non-specific low back pain in Hong Kong: a randomised controlled trial.

    Abstract Source:

    Complement Ther Med. 2004 Mar;12(1):28-37. PMID: 15130569

    Abstract Author(s):

    Y B Yip, S H M Tse

    Abstract:

    OBJECTIVES: To assess the effect of acupoint stimulation with electrodes combined with acupressure using an aromatic essential oil (lavender) as an add-on-treatment on pain relief and enhancing the physical functional activities among adults with sub-acute or chronic non-specific low back pain. DESIGN: Randomised controlled trial. SETTING: The community centre, Old-Aged Home and Women Workers Association, Hong Kong. Intervention: 8-session relaxation acupoint stimulation followed by acupressure with lavender oil over a 3-week period. The control group received usual care only. OUTCOME MEASURES: Changes from baseline to the end of treatment were assessed in pain intensity (by Visual Analogue Scale) and duration; lateral fingertip-to-ground distance in centimetres; walking time and interference on daily activities. RESULTS: The baseline VAS scores for the intervention and control groups were 6.38 (S.E.M. = 0.22) and 5.70 (S.E.M. = 0.37) out of 10, respectively ( P=0.24 ). One week after the end of treatment, the intervention group had 39% greater reduction in VAS pain intensity than the control group ( P=0.0001 ), improved walking time ( P=0.05 ) and greater lateral spine flexion range ( P=0.01 ). CONCLUSIONS: Our results show that 8-sessions of acupoint stimulation followed by acupressure with aromatic lavender oil were an effective method for short-term LBP relief. No adverse effects were reported. To complement mainstream medical treatment for sub-acute LBP, the combined therapy of acupoint stimulation followed by acupressure with aromatic lavender oil may be one of the choices as an add-on therapy for short-term reduction of LBP.

  • The effects of aromatherapy on nicotine craving on a U.S. campus: a small comparison study.

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    Abstract Title:

    The effects of aromatherapy on nicotine craving on a U.S. campus: a small comparison study.

    Abstract Source:

    J Altern Complement Med. 2013 Aug ;19(8):709-13. Epub 2013 Mar 28. PMID: 23536963

    Abstract Author(s):

    Barbara Cordell, Jane Buckle

    Article Affiliation:

    Barbara Cordell

    Abstract:

    OBJECTIVES:To evaluate the effect of two inhaled essential oils (black pepper or angelica) on the nicotine habits of students, staff, and faculty on a U.S. college campus.

    DESIGN:Comparative study with pre-/post-test measures.

    SETTING:Community college in rural East Texas.

    PARTICIPANTS:Convenience sample of 20 volunteers from the college community (students, faculty, and staff) who were regular (daily) users of nicotine (cigarettes, snuff, or chewing tobacco).

    INTERVENTIONS:Inhalation of one drop of essential oil on a tissue for 2 minutes when participant was craving nicotine.

    OUTCOME MEASURES:(1) Pre-inhalation journal recording of self-assessed level of craving for nicotine on a 0-10 scale, (2) post-inhalation journal recording of self-assessed level of craving for nicotine on a 0-10 scale, and (3) minutes that participant waited from start of inhalation until next use of tobacco.

    RESULTS:Both black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco. However, black pepper reduced the level of craving more than did angelica, and angelica allowed for a longer delay than did black pepper.

    CONCLUSIONS:Aromatherapy may be useful in nicotine withdrawal. Further studies are warranted.

  • The effects of aromatherapy on pain, depression, and life satisfaction of arthritis patients

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    Abstract Title:

    [The effects of aromatherapy on pain, depression, and life satisfaction of arthritis patients].

    Abstract Source:

    Taehan Kanho Hakhoe Chi. 2005 Feb ;35(1):186-94. PMID: 15778570

    Abstract Author(s):

    Myung-Ja Kim, Eun-Sook Nam, Seun-In Paik

    Article Affiliation:

    College of Nursing, The Catholic University of Korea, Korea.

    Abstract:

    PURPOSE:The purpose of this study was to investigate the effect of aromatherapy on pain, depression, and feelings of satisfaction in life of arthritis patients.

    METHOD:This study used a quasi-experimental design with a non-equivalent control group, pre-and post-test. The sample consisted of 40 patients, enrolled in the Rheumatics Center, Kangnam St. Mary's Hospital, South Korea. The essential oils used were lavender, marjoram, eucalyptus, rosemary, and peppermint blended in proportions of 2:1:2:1:1. They were mixed with a carrier oil composed of almond (45%), apricot(45%), and jojoba oil(10%) and they were diluted to 1.5% after blending. The data were analyzed using an 2-test, Fisher's exact test, t-test and paired t-test.

    RESULT:Aromatherapy significantly decreased both the pain score and the depression score of the experimental group compared with the control group. However, aromatherapy didn't increase the feeling of satisfaction in life of the experimental group compared with the control group.

    CONCLUSION:The result of this study clearly shows that aromatherapy has major effects on decreasing pain and depression levels. Based on our experiment's findings, we suggest that aromatherapy can be a useful nursing intervention for arthritis patients.

  • The effects of aromatherapy on sleep improvement: a systematic literature review and meta-analysis.

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    Abstract Title:

    The effects of aromatherapy on sleep improvement: a systematic literature review and meta-analysis.

    Abstract Source:

    J Altern Complement Med. 2015 Feb ;21(2):61-8. Epub 2015 Jan 13. PMID: 25584799

    Abstract Author(s):

    Eunhee Hwang, Sujin Shin

    Article Affiliation:

    Eunhee Hwang

    Abstract:

    OBJECTIVES:To evaluate the existing data on aromatherapy interventions for improvement of sleep quality.

    DESIGN:Systematic literature review and meta-analysis on the effects of aromatherapy. Study Sources: Electronic databases, including the Korea Education and Research Information Service (KERIS), Korean studies Information Service System (KISS), National Assembly Library, and eight academies within the Korean Society of Nursing Science, were searched to identify studies published between 2000 and August 2013.

    STUDY SELECTION:Randomized controlled and quasi-experimental trials that included aromatherapy for the improvement of sleep quality. Of the 245 publications identified, 13 studies met the inclusion and exclusion criteria, and 12 studies were used in the meta-analysis.

    RESULTS:Meta-analysis of the 12 studies using a random-effects model revealed that the use of aromatherapy was effective in improving sleep quality (95% confidence interval [CI], 0.540-1.745; Z=3.716). Subgroup analysis revealed that inhalation aromatherapy (95% CI, 0.792-1.541; Z=6.107) was more effective than massage therapy (95% CI, 0.128-2.166; Z=2.205) in unhealthy (95% CI, 0.248-1.100; Z=3.100) and healthy (95% CI, 0.393-5.104; Z=2.287) participants, respectively.

    CONCLUSION:Readily available aromatherapy treatments appear to be effective and promote sleep. Thus, it is essential to develop specific guidelines for the efficient use of aromatherapy.

  • The Effects of Inhalation Aromatherapy with Rose and Lavender at Week 38 and Postpartum Period on Postpartum Depression in High-risk Women Referred to Selected Health Centers of Yazd, Iran in 2015📎

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    Abstract Title:

    The Effects of Inhalation Aromatherapy with Rose and Lavender at Week 38 and Postpartum Period on Postpartum Depression in High-risk Women Referred to Selected Health Centers of Yazd, Iran in 2015.

    Abstract Source:

    Iran J Nurs Midwifery Res. 2018 Sep-Oct;23(5):395-401. PMID: 30186346

    Abstract Author(s):

    Maryam Kianpour, Fateme Moshirenia, GolamReza Kheirabadi, GolamReza Asghari, Ali Dehghani, Arefah Dehghani-Tafti

    Article Affiliation:

    Maryam Kianpour

    Abstract:

    Background:Postpartum depression (PPD) is one of the most common problems in women of childbearing age. This study was conducted to evaluate the efficacy of aromatherapy on PPD.

    Materials and Methods:In this study, 105 pregnant women at 35-37 weeks of pregnancy were enrolled using convenient sampling and randomly assigned to three groups. The intervention group dropped 7 drops of lavender oil and 1 cc rose water at the concentration of 100%, and the placebo group dropped 7 drops of odorless sesame seed oil, with 1 cc of musk willow sweat at the concentration of 100% by dropper on a special cloth. They put the cloths on their mouths and took 10 deep breaths before sleeping and then placed them next to their pillows. The control group only received the routine care. The intervention lasted from 38week of pregnancy until 6 weeks after delivery. Then depression level was determined before the intervention, 35-37 weeks of pregnancy, 2 and 6 weeks after delivery using Edinburgh questionnaire.

    Results:The mean of depression score in the intervention group decreased significantly compared to the placebo and control groups, 2 weeks (= 9.412,<0.001) and 6 weeks after delivery (= 7.813,<0.01).

    Conclusions:This study provides valid evidence for the effect of aromatherapy on PPD. Therefore, the use of aromatherapy can be recommended in high.

  • The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity.

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    Abstract Title:

    The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity.

    Abstract Source:

    J Med Assoc Thai. 2012 Apr ;95(4):598-606. PMID: 22612017

    Abstract Author(s):

    Winai Sayorwan, Vorasith Siripornpanich, Teerut Piriyapunyaporn, Tapanee Hongratanaworakit, Naiphinich Kotchabhakdi, Nijsiri Ruangrungsi

    Article Affiliation:

    College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand.

    Abstract:

    OBJECTIVE:Investigate the effects of lavender oil on the central nervous system, autonomic nervous system, and mood responses in humans after inhalation.

    MATERIAL AND METHOD:Twenty healthy volunteers participated in the experiments. The present study assessed autonomic parameters such as blood pressure, heart rate, respiratory rate, and skin temperature to determine the arousal level of the autonomic nervous system. In addition, subjects were asked to estimate their mood responses such as feeling pleasant or unpleasant, uncomfortable, sensuality, relaxation, or refreshing in order to assess subjective behavioral arousal. Finally, electroencephalogram (EEG) was recorded from 31 electrodes on the scalp according to the international 10 to 20 system, and EEG power spectra were calculated by Fast Fourier Transform (FFT). Data was analyzed by comparing the effects of lavender oil on physiological and mood states with sweet almond oil. These assessments were measured before and after using paired t-test statistical procedure.

    RESULTS:The results revealed that lavender oil caused significant decreases of blood pressure, heart rate, and skin temperature, which indicated a decrease of autonomic arousal. In terms of mood responses, the subjects in the lavender oil group categorized themselves as more active, fresher relaxed than subjects just inhaling base oil. Compared with base oil, lavender oil increased the power of theta (4-8 Hz) and alpha (8-13 Hz) brain activities. The topographic map showed obviously more scattering power in alpha range waves particularly in bilateral temporal and central area.

    CONCLUSION:The findings provided evidence the relaxing effect of inhaling lavender oil.

  • The effects of the inhalation method using essential oils on blood pressure and stress responses of clients with essential hypertension

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    Abstract Title:

    [The effects of the inhalation method using essential oils on blood pressure and stress responses of clients with essential hypertension].

    Abstract Source:

    Taehan Kanho Hakhoe Chi. 2006 Dec;36(7):1123-34. PMID: 17211115

    Abstract Author(s):

    Jin-Hee Hwang

    Abstract:

    PURPOSE: The purpose of this study was to identify the effects of aromatherapy on blood pressure and stress responses of clients with essential hypertension. METHOD: There were fifty-two subjects divided into an essential oil group, placebo group, and control group by random assignment. The application of aromatherapy was the inhalation method of blending oils with lavender, ylangylang, and bergamot once daily for 4 weeks. To evaluate the effects of aromatherapy, blood pressure and pulse were measured two times a week and serum cortisol levels, catecholamine levels, subjective stress, and state anxiety were measured before and after treatment in the three groups. Data was analyzed by repeated measures of ANOVA, one-way ANOVA, and chi(2)-test using the SPSS 10.0 program. RESULTS: The blood pressure, pulse, subjective stress, state anxiety, and serum cortisol levels among the three groups were significantly statistically different. The differences of catecholamine among the three groups were not significant statistically. CONCLUSION: The results suggest that the inhalation method using essential oils can be considered an effective nursing intervention that reduces psychological stress responses and serum cortisol levels, as well as the blood pressure of clients with essential hypertension.

  • The efficacy of the application of essential oils for the prevention of acute respiratory diseases in organized groups of children

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    Abstract Title:

    [The efficacy of the application of essential oils for the prevention of acute respiratory diseases in organized groups of children].

    Abstract Source:

    Vestn Otorinolaringol. 2011(5):51-4. PMID: 22334926

    Abstract Author(s):

    A V Kilina, M B Kolesnikova

    Abstract:

    The efficacy and safety of the application of essential oils for the prevention of acute respiratory diseases and alleviation of clinical manifestations of rhinitis was evaluated in a group of children aged 3-4 years. It was shown that inhalation of a mixture of essential oils resulted in a 42.5% decrease of the prevalence of the above pathologies. Specifically, they developed only in each third child from the group of frequently ill children. No side effects of the treatment were documented. 25% of the children suffered only from mild acute respiratory diseases, fever was absent in 5%. The severity and duration of the symptoms of rhinitis decreased in more than 80% of the children. Simultaneously, the requirement of decongestants and local (intranasal) antibiotics was reduced.

  • The psychological effects of aromatherapy-massage in healthy postpartum mothers.

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    Abstract Title:

    The psychological effects of aromatherapy-massage in healthy postpartum mothers.

    Abstract Source:

    J Midwifery Womens Health. 2006 Mar-Apr;51(2):e21-7. PMID: 16504900

    Abstract Author(s):

    Masumi Imura, Hanako Misao, Hiroshi Ushijima

    Abstract:

    This study examined the effect of aromatherapy-massage in healthy postpartum mothers. A quasi-experimental between-groups design was used. Mothers who received aromatherapy-massage were compared with a control group who received standard postpartum care. Thirty-six healthy, first-time mothers with vaginal delivery of a full-term, healthy infant participated in this study. Sixteen mothers received a 30-minute aromatherapy-massage on the second postpartum day; 20 mothers were in the control group. All mothers completed the following four standardized questionnaires before and after the intervention: 1) Maternity Blues Scale; 2) State-Trait Anxiety Inventory; 3) Profile of Mood States (POMS); and 4) Feeling toward Baby Scale. In the aromatherapy-massage group, posttreatment scores significantly decreased for the Maternity Blues Scale, the State-Anxiety Inventory, and all but one of the Profile of Mood States subscales. Posttreatment scores in the intervention group significantly increased in Profile of Mood States-Vigor subscale and the Approach Feeling toward Baby subscale. Scores in the intervention group significantly decreased in Conflict Index of Avoidance/Approach Feeling toward Baby subscale. Our results suggest that aromatherapy-massage might be an effective intervention for postpartum mothers to improve physical and mental status and to facilitate mother-infant interaction.

  • The study protocol of a blinded randomised-controlled cross-over trial of lavender oil as a treatment of behavioural symptoms in dementia📎

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    Abstract Title:

    The study protocol of a blinded randomised-controlled cross-over trial of lavender oil as a treatment of behavioural symptoms in dementia.

    Abstract Source:

    BMC Geriatr. 2010 ;10:49. Epub 2010 Jul 22. PMID: 20649945

    Abstract Author(s):

    Eva S van der Ploeg, Barbara Eppingstall, Daniel W O'Connor

    Article Affiliation:

    Aged Mental Health Research Unit, Monash University, Kingston Centre, Warrigal Road, Cheltenham, Melbourne, VIC 3192, Australia. This email address is being protected from spambots. You need JavaScript enabled to view it.

    Abstract:

    BACKGROUND:The agitated behaviours that accompany dementia (e.g. pacing, aggression, calling out) are stressful to both nursing home residents and their carers and are difficult to treat. Increasingly more attention is being paid to alternative interventions that are associated with fewer risks than pharmacology. Lavandula angustifolia (lavender) has been thought, for centuries, to have soothing properties, but the existing evidence is limited and shows mixed results. The aim of the current study is to test the effectiveness of topically applied pure lavender oil in reducing actual counts of challenging behaviours in nursing home residents.

    METHODS/DESIGN:We will use a blinded repeated measures design with random cross-over between lavender oil and placebo oil. Persons with moderate to severe dementia and associated behavioural problems living in aged care facilities will be included in the study. Consented, willing participants will be assigned in random order to lavender or placebo blocks for one week then switched to the other condition for the following week. In each week the oils will be applied on three days with at least a two-day wash out period between conditions. Trained observers will note presence of target behaviours and predominant type of affect displayed during the 30 minutes before and the 60 minutes after application of the oil. Nursing staff will apply 1 ml of 30% high strength essential lavender oil to reduce the risk of missing a true effect through under-dosing. The placebo will comprise of jojoba oil only. The oils will be identical in appearance and texture, but can easily be identified by smell. For blinding purposes, all staff involved in applying the oil or observing the resident will apply a masking cream containing a mixture of lavender and other essential oils to their upper lip. In addition, nursing staff will wear a nose clip during the few minutes it takes to massage the oil to the resident's forearms.

    DISCUSSION:If our results show that the use of lavender oil is effective in reducing challenging behaviours in individuals with dementia, it will potentially provide a safer intervention rather than reliance on pharmacology alone. The study's findings will translate easily to other countries and cultures.

    TRIAL REGISTRATION:Australian New Zealand Clinical Trials Registry - ACTRN 12609000569202.

  • Unraveling the Rat Intestine, Spleen and Liver Genome-Wide Transcriptome after the Oral Administration of Lavender Oil by a Two-Color Dye-Swap DNA Microarray Approach📎

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    Abstract Title:

    Unraveling the Rat Intestine, Spleen and Liver Genome-Wide Transcriptome after the Oral Administration of Lavender Oil by a Two-Color Dye-Swap DNA Microarray Approach.

    Abstract Source:

    PLoS One. 2015 ;10(7):e0129951. Epub 2015 Jul 10. PMID: 26161641

    Abstract Author(s):

    Hiroko Kubo, Junko Shibato, Tomomi Saito, Tetsuo Ogawa, Randeep Rakwal, Seiji Shioda

    Article Affiliation:

    Hiroko Kubo

    Abstract:

    The use of lavender oil (LO) - a commonly, used oil in aromatherapy, with well-defined volatile components linalool and linalyl acetate - in non-traditional medicine is increasing globally. To understand and demonstrate the potential positive effects of LO on the body, we have established an animal model in this current study, investigating the orally administered LO effects genome wide in the rat small intestine, spleen, and liver. The rats were administered LO at 5 mg/kg (usual therapeutic dose in humans) followed by the screening of differentially expressed genes in the tissues, using a 4×44-K whole-genome rat chip (Agilent microarray platform; Agilent Technologies, Palo Alto, CA, USA) in conjunction with a dye-swap approach, a novelty of this study. Fourteen days after LO treatment and compared with a control group (sham), a total of 156 and 154 up (≧ 1.5-fold)- and down (≦ 0.75-fold)-regulated genes, 174 and 66 up- (≧ 1.5-fold)- and down (≦ 0.75-fold)-regulated genes, and 222 and 322 up- (≧ 1.5-fold)- and down (≦ 0.75-fold)-regulated genes showed differential expression at the mRNA level in the small intestine, spleen and liver, respectively. The reverse transcription-polymerase chain reaction (RT-PCR) validation of highly up- and down-regulated genes confirmed the regulation of the Papd4, Lrp1b, Alb, Cyr61, Cyp2c, and Cxcl1 genes by LO as examples in these tissues. Using bioinformatics, including Ingenuity Pathway Analysis (IPA), differentially expressedgenes were functionally categorized by their Gene Ontology (GO) and biological function and network analysis, revealing their diverse functions and potential roles in LO-mediated effects in rat. Further IPA analysis in particular unraveled the presence of novel genes, such as Papd4, Or8k5, Gprc5b, Taar5, Trpc6, Pld2 and Onecut3 (up-regulated top molecules) and Tnf, Slc45a4, Slc25a23 and Samt4 (down-regulated top molecules), to be influenced by LO treatment in the small intestine, spleen and liver, respectively. These results are the first such inventory of genes that are affected by lavender essential oil (LO) in an animal model, forming the basis for further in-depth bioinformatics and functional analyses and investigation.

  • Volatiles emitted from the leaves of Laurus nobilis L. improve vigilance performance in visual discrimination task📎

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    Abstract Title:

    Volatiles emitted from the leaves of Laurus nobilis L. improve vigilance performance in visual discrimination task.

    Abstract Source:

    Biomed Res. 2011;32(1):19-28. PMID: 21383507

    Abstract Author(s):

    Eri Matsubara, Mio Fukagawa, Tsuyoshi Okamoto, Atsuko Fukuda, Chikako Hayashi, Koichiro Ohnuki, Kuniyoshi Shimizu, Ryuichiro Kondo

    Article Affiliation:

    Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, Japan.

    Abstract:

    The leaves of Laurus noblis L. (laurel) are mainly used as a spice in cooking, and the essential oil obtained by steam distillation of the leaves is used as an additive in foods, drugs and cosmetics. We investigated the effect of the volatiles emitted from the leaves of L. noblis at different doses (low-dose and high-dose groups) on vigilance performance in a visual discrimination task. By inhaling volatiles of the leaves of L. noblis, the decrease of the rate of true hits found in the control group was prevented in the low-dose group. The high-dose group showed higher scores than the low-dose group for subjective effects related to negative emotion. Meanwhile, both groups showed physiological effects suggesting stimulation of circulation. These findings suggest that the volatiles emitted from the leaves of L. noblis at low concentration could be utilized to maintain a high level of vigilance performance, such as the rate of true hits by improving physiological arousal without incurring the detrimental performance effects of negative emotion.