Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer.
Am J Surg. 2008 Oct;196(4):523-6. PMID: 18809055
Nimmi Arora, Diana Martins, Danielle Ruggerio, Eleni Tousimis, Alexander J Swistel, Michael P Osborne, Rache M Simmons
Department of Surgery, New York Presbyterian Hospital-Cornell, New York, NY, USA.
BACKGROUND: Digital infrared thermal imaging (DITI) has resurfaced in this era of modernized computer technology. Its role in the detection of breast cancer is evaluated.
METHODS: In this prospective clinical trial, 92 patients for whom a breast biopsy was recommended based on prior mammogram or ultrasound underwent DITI. Three scores were generated: an overall risk score in the screening mode, a clinical score based on patient information, and a third assessment by artificial neural network.
RESULTS: Sixty of 94 biopsies were malignant and 34 were benign. DITI identified 58 of 60 malignancies, with 97% sensitivity, 44% specificity, and 82% negative predictive value depending on the mode used. Compared to an overall risk score of 0, a score of 3 or greater was significantly more likely to be associated with malignancy (30% vs 90%, P<.03).
CONCLUSION: DITI is a valuable adjunct to mammography and ultrasound, especially in women with dense breast parenchyma.
Article Published Date : Oct 01, 2008
Efficacy of computerized infrared imaging analysis to evaluate mammographically suspicious lesions.
AJR Am J Roentgenol. 2003 Jan;180(1):263-9. PMID: 12490517
Y R Parisky, A Sardi, R Hamm, K Hughes, L Esserman, S Rust, K Callahan
USC/Norris Cancer Center, 1441 Eastlake Ave., Los Angeles, CA 90033, USA.
OBJECTIVE: The purpose of this clinical trial was to determine the efficacy of a dynamic computerized infrared imaging system for distinguishing between benign and malignant lesions in patients undergoing biopsy on the basis of mammographic findings.
SUBJECTS AND METHODS: A 4-year clinical trial was conducted at five institutions using infrared imaging of patients for whom breast biopsy had been recommended. The data from a blinded subject set were obtained in 769 subjects with 875 biopsied lesions resulting in 187 malignant and 688 benign findings. The infrared technique records a series of sequential images that provides an assessment of the infrared information in a mammographically identified area. The suspicious area is localized on the infrared image by the radiologist using mammograms, and an index of suspicion is determined, yielding a negative or positive result.
RESULTS: In the 875 biopsied lesions, the index of suspicion resulted in a 97% sensitivity, a 14% specificity, a 95% negative predictive value, and a 24% positive predictive value. Lesions that were assessed as false-negative by infrared analysis were microcalcifications, so an additional analysis was performed in a subset excluding lesions described only as microcalcification. In this restricted subset of 448 subjects with 479 lesions and 110 malignancies, the index of suspicion resulted in a 99% sensitivity, an 18% specificity, a 99% negative predictive value, and a 27% positive predictive value. Analysis of infrared imaging performance in all 875 biopsied lesions revealed that specificity was statistically improved in dense breast tissue compared with fatty breast tissue.
CONCLUSION: Infrared imaging offers a safe noninvasive procedure that would be valuable as an adjunct to mammography in determining whether a lesion is benign or malignant.
Article Published Date : Jan 01, 2003
Study Type : Human Study
Reporting of thermography parameters in biology: a systematic review of thermal imaging literature.
R Soc Open Sci. 2018 Dec;5(12):181281
Authors: Harrap MJM, Hempel de Ibarra N, Whitney HM, Rands SA
Infrared (IR) thermography, where temperature measurements are made with IR cameras, has proven to be a very useful and widely used tool in biological science. Several thermography parameters are critical to the proper operation of thermal cameras and the accuracy of measurements, and these must usually be provided to the camera. Failure to account for these parameters may lead to less accurate measurements. Furthermore, the failure to provide information of parameter choices in reports may compromise appraisal of accuracy and replicate studies. In this review, we investigate how well biologists report thermography parameters. This is done through a systematic review of biological thermography literature that included articles published between years 2007 and 2017. We found that in primary biological thermography papers, which make some kind of quantitative temperature measurement, 48% fail to report values used for emissivity (an object's capacity to emit thermal radiation relative to a black body radiator), which is the minimum level of reporting that should take place. This finding highlights the need for life scientists to take into account and report key parameter information when carrying out thermography, in the future.
PMID: 30662737 [PubMed]
Thermoregulation in rapid growing broiler chickens is compromised by constraints on radiative and convective cooling performance.
J Therm Biol. 2019 Jan;79:8-14
Authors: Tickle PG, Codd JR
Broiler chickens are selected to undergo a rapid six-week hatch-to-slaughter growth phase to attain large body and muscle mass. Broilers have relatively high resting and locomotor metabolic costs suggesting that adaptive thermoregulatory mechanisms are required to dissipate excess heat. Using thermal imaging in the growing broiler we characterised the trajectory of radiative and convective cooling in still air across broiler development. Scaling of head, tarsus and toe surface area did not deviate from body mass2/3 while torso area increased with positive allometry, body mass0.82, reflecting increased feather coverage and/or disproportionate abdominal/thoracic growth. Despite relatively increased area, the body became less effective for heat transfer presumably due to increasing feather coverage. Conversely, the magnitude of heat exchange from the distal hindlimbs was improved in larger birds. Overall capacity to transfer heat by convection and radiation in still air was attenuated over development, since the proportion of resting metabolic rate accounted for decreased in standing and sitting postures. This physiological constraint could be ameliorated by increased latent heat transfer or provision of environmental ventilation, which we modelled according to industrial guidelines. Based on models, higher airspeeds coincided with improved convective cooling that assisted in maintaining the proportion of RMR accounted for by convective and radiative heat transfer. These data highlight the potentially adverse thermoregulatory effects of rapid growth rate and body mass increases, which may contribute to the increased sedentary resting and decreased locomotor behaviour observed in large broilers.
PMID: 30612689 [PubMed - indexed for MEDLINE]