Cybermedlife - Therapeutic Actions Sweating

Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study. 📎

Abstract Title: Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study. Abstract Source: Biomed Res Int. 2017 ;2017:3676089. Epub 2017 Mar 8. PMID: 28373979 Abstract Author(s): Shelagh K Genuis, Detlef Birkholz, Stephen J Genuis Article Affiliation: Shelagh K Genuis Abstract: Commonly used as flame retardants, polybrominated diphenyl ethers (PBDEs) are routinely detected in the environment, animals, and humans. Although these persistent organic pollutants are increasingly recognized as having serious health implications, particularly for children, this is the first study, to our knowledge, to investigate an intervention for human elimination of bioaccumulated PBDEs. Objectives. To determine the efficacy of blood, urine, and perspiration as PBDE biomonitoring mediums; assess excretion of five common PBDE congeners (28, 47, 99, 100, and 153) in urine and perspiration; and explore the potential of induced sweating for decreasing bioaccumulated PBDEs. Results. PBDE congeners were not found in urine samples; findings focus on blood and perspiration. 80% of participants tested positive in one or more body fluids for PBDE 28, 100% for PBDE 47, 95% for PBDE 99, and 90% for PBDE 100 and PBDE 153. Induced perspiration facilitated excretion of the five congeners, with different rates of excretion for different congeners. Conclusion. Blood testing provides only a partial understanding of human PBDE bioaccumulation; testing of both blood and perspiration provides a better understanding. This study provides important baseline evidence for regular induced perspiration as a potential means for therapeutic PBDE elimination. Fetotoxic and reproductive effects of PBDE exposure highlight the importance of further detoxification research. Article Published Date : Dec 31, 2016

Arsenic, cadmium, lead, and mercury in sweat: a systematic review. 📎

Abstract Title: Arsenic, cadmium, lead, and mercury in sweat: a systematic review. Abstract Source: J Environ Public Health. 2012 ;2012:184745. Epub 2012 Feb 22. PMID: 22505948 Abstract Author(s): Margaret E Sears, Kathleen J Kerr, Riina I Bray Article Affiliation: Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada K1H 8L1. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: Arsenic, cadmium, lead, and mercury exposures are ubiquitous. These toxic elements have no physiological benefits, engendering interest in minimizing body burden. The physiological process of sweating has long been regarded as"cleansing"and of low risk. Reports of toxicant levels in sweat were sought in Medline, Embase, Toxline, Biosis, and AMED as well as reference lists and grey literature, from inception to March 22, 2011. Of 122 records identified, 24 were included in evidence synthesis. Populations, and sweat collection methods and concentrations varied widely. In individuals with higher exposure or body burden, sweat generally exceeded plasma or urine concentrations, and dermal could match or surpass urinary daily excretion. Arsenic dermal excretion was severalfold higher in arsenic-exposed individuals than in unexposed controls. Cadmium was more concentrated in sweat than in blood plasma. Sweat lead was associated with high-molecular-weight molecules, and in an interventional study, levels were higher with endurance compared with intensive exercise. Mercury levels normalized with repeated saunas in a case report. Sweating deserves consideration for toxic element detoxification. Research including appropriately sized trials is needed to establish safe, effective therapeutic protocols. Article Published Date : Dec 31, 2011

Human elimination of phthalate compounds: blood, urine, and sweat (BUS) study. 📎

Abstract Title: Human elimination of phthalate compounds: blood, urine, and sweat (BUS) study. Abstract Source: ScientificWorldJournal. 2012 ;2012:615068. Epub 2012 Oct 31. PMID: 23213291 Abstract Author(s): Stephen J Genuis, Sanjay Beesoon, Rebecca A Lobo, Detlef Birkholz Article Affiliation: Faculty of Medicine, University of Alberta, 2935-66 Street, Edmonton, AB T6K 4C1, Canada. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: BACKGROUND: Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups. Multiple epidemiological studies have demonstrated statistically significant exposure-disease relationships involving phthalates and toxicological studies have shown estrogenic effects in vitro. Data is lacking in the medical literature, however, on effective means to facilitate phthalate excretion. METHODS: Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for parent phthalate compounds as well as phthalate metabolites using high performance liquid chromatography-tandem mass spectrometry. RESULTS: Some parent phthalates as well as their metabolites were excreted into sweat. All patients had MEHP (mono(2-ethylhexyl) phthalate) in their blood, sweat, and urine samples, suggesting widespread phthalate exposure. In several individuals, DEHP (di (2-ethylhexl) phthalate) was found in sweat but not in serum, suggesting the possibility of phthalate retention and bioaccumulation. On average, MEHP concentration in sweat was more than twice as high as urine levels. CONCLUSIONS: Induced perspiration may be useful to facilitate elimination of some potentially toxic phthalate compounds including DEHP and MEHP. Sweat analysis may be helpful in establishing the existence of accrued DEHP in the human body. Article Published Date : Dec 31, 2011

Human excretion of bisphenol A: blood, urine, and sweat (BUS) study. 📎

Abstract Title: Human excretion of bisphenol A: blood, urine, and sweat (BUS) study. Abstract Source: J Environ Public Health. 2012 ;2012:185731. Epub 2011 Dec 27. PMID: 22253637 Abstract Author(s): Stephen J Genuis, Sanjay Beesoon, Detlef Birkholz, Rebecca A Lobo Article Affiliation: Faculty of Medicine, University of Alberta, Edmonton, Canada. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: BACKGROUND: Bisphenol A (BPA) is an ubiquitous chemical contaminant that has recently been associated with adverse effects on human health. There is incomplete understanding of BPA toxicokinetics, and there are no established interventions to eliminate this compound from the human body. Using 20 study participants, this study was designed to assess the relative concentration of BPA in three body fluids-blood, urine, and sweat-and to determine whether induced sweating may be a therapeutic intervention with potential to facilitate elimination of this compound. METHODS: Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for various environmental toxicants including BPA. RESULTS: BPA was found to differing degrees in each of blood, urine, and sweat. In 16 of 20 participants, BPA was identified in sweat, even in some individuals with no BPA detected in their serum or urine samples. CONCLUSIONS: Biomonitoring of BPA through blood and/or urine testing may underestimate the total body burden of this potential toxicant. Sweat analysis should be considered as an additional method for monitoring bioaccumulation of BPA in humans. Induced sweating appears to be a potential method for elimination of BPA. Article Published Date : Dec 31, 2011

Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements.

Abstract Title: Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements. Abstract Source: Arch Environ Contam Toxicol. 2011 Aug ;61(2):344-57. Epub 2010 Nov 6. PMID: 21057782 Abstract Author(s): Stephen J Genuis, Detlef Birkholz, Ilia Rodushkin, Sanjay Beesoon Article Affiliation: University of Alberta, Edmonton, AB, Canada. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: There is limited understanding of the toxicokinetics of bioaccumulated toxic elements and their methods of excretion from the human body. This study was designed to assess the concentration of various toxic elements in three body fluids: blood, urine and sweat. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with various health problems) and analyzed for approximately 120 various compounds, including toxic elements. Toxic elements were found to differing degrees in each of blood, urine, and sweat. Serum levels for most metals and metalloids were comparable with those found in other studies in the scientific literature. Many toxic elements appeared to be preferentially excreted through sweat. Presumably stored in tissues, some toxic elements readily identified in the perspiration of some participants were not found in their serum. Induced sweating appears to be a potential method for elimination of many toxic elements from the human body. Biomonitoring for toxic elements through blood and/or urine testing may underestimate the total body burden of such toxicants. Sweat analysis should be considered as an additional method for monitoring bioaccumulation of toxic elements in humans. Article Published Date : Jul 31, 2011
Therapeutic Actions Sweating

NCBI pubmed

Rapid saline infusion and/or drinking enhance skin sympathetic nerve activity components reduced by hypovolaemia and hyperosmolality in hyperthermia.

Rapid saline infusion and/or drinking enhance skin sympathetic nerve activity components reduced by hypovolaemia and hyperosmolality in hyperthermia. J Physiol. 2018 Sep 22;: Authors: Kamijo YI, Okazaki K, Ikegawa S, Okada Y, Nose H Abstract KEY POINT SUMMARY: In hyperthermia, plasma hyperosmolality suppresses both cutaneous vasodilatation and sweating responses and these suppressions are removed by oropharyngeal stimulation such as drinking. Hypovolaemia suppresses only cutaneous vasodilatation, which is enhanced by rapid infusion in hyperthermia. Our recent studies suggest that skin sympathetic nerve activity (SSNA) involved components synchronised and non-synchronised with the cardiac cycle, which are associated with an active vasodilator and a sudomotor, respectively. In the present study, plasma hyperosmolality suppressed both components, drinking removed the hyperosmolality-induced suppressions, simultaneously with increases in cutaneous vasodilatation and sweating with not altering plasma volume and osmolality. Furthermore, a rapid saline infusion increased synchronised component and cutaneous vasodilatation in hypovolaemic and hyperthermic humans. The results support our idea that SSNA involves active cutaneous vasodilator and sudomotor and a site where osmolality signals are projected to control thermoregulation is located more superior than the medulla where signals from baroreceptors are projected. ABSTRACT: We reported that skin sympathetic nerve activity (SSNA) involved components synchronised and non-synchronised with the cardiac cycle, both components increased in hyperthermia and our results suggest that the components are associated with active vasodilator and sudomotor, respectively. In the present study, we examined whether the increases in the components in hyperthermia would be suppressed by plasma hyperosmolality simultaneously with suppressions of cutaneous vasodilatation and sweating and whether these suppressions were released by oropharyngeal stimulation (drinking). Also, effects of a rapid saline infusion on the both components and responses of cutaneous vasodilatation and sweating were tested in hypovolaemic and hyperthermic subjects. We found that 1) plasma hyperosmolality suppressed both components in hyperthermia, 2) the suppressions were released by drinking of 200-mL water simultaneously with enhanced cutaneous vasodilatation and sweating responses, and 3) a rapid infusion; at 1.0 and 0.2 ml min-1  kg-1 for the first 10 min and the following 20 min, respectively, increased the synchronised component and cutaneous vasodilatation in diuretic-induced hypovolaemia greater than those in time control; at 0.1 ml min-1  kg-1 for 30 min, and no greater increases in the non-synchronised component and sweating responses were observed during rapid infusion than time control. The results support the idea that SSNA involves the components synchronised and non-synchronised with the cardiac cycle, associated with the active cutaneous vasodilator and sudomotor, and a site of osmolality-induced modulation for thermoregulation is located superior to the medulla where signals from baroreceptors are projected. This article is protected by copyright. All rights reserved. PMID: 30242837 [PubMed - as supplied by publisher]

Feasibility of a Kinect®-based rehabilitation strategy after burn injury.

Related Articles Feasibility of a Kinect®-based rehabilitation strategy after burn injury. Burns. 2018 Sep 18;: Authors: Pham TN, Wong JN, Terken T, Gibran NS, Carrougher GJ, Bunnell A Abstract INTRODUCTION: The advent of consoles that deliver both interactive games and therapy may augment rehabilitation options in burn patients. The Jintronix software combines therapy-specific software and interactive gaming as a form of coaching and records patient performance on the Kinect® platform. Our objective was to determine the feasibility of a set of Jintronix games and therapy modules in hospitalized adult burn patients. METHODS: We conducted a prospective single center feasibility study from August through October 2016. The study enrolled subjects to conduct 1 supervised session with 6 Jintronix modules targeting their burned areas of the body, with an acceptability survey and a safety analysis. We also performed qualitative analysis to detect major themes from free-text responses. RESULTS: We enrolled 20 participants. Eleven (55%) completed all the modules; reasons for incompletion included baseline shoulder abduction pain and poor balance. Participants responded that the activity was comfortable (90%), safe (100%), easy to understand (95%), and improved strength/range of motion (100%). Mean module completion time was 43±10min. Mean pain score was 3.8±2.8 (out of 10) and localized to burned areas. The wall climbing module had 4 episodes of temporary imbalance. Eight (40%) participants recorded fatigue at completion and noted "sweating" or "feeling stretched". Qualitative analysis highlighted that the activity was "fun/cool" and a "good challenge". Negative themes included "inaccurate depth" sensing and "too lengthy" on a specific module. CONCLUSIONS: A Jintronix-based therapy demonstrated good acceptability and safety in hospitalized burn patients. Feedback from this study led to software modifications implemented by the Jintronix company. This feasibility study has informed the design of a prospective randomized controlled trial to determine whether a virtual-environment home rehabilitation strategy improves functional outcomes after burn injury. PMID: 30241787 [PubMed - as supplied by publisher]