CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Cybermedlife - Therapeutic Actions Positive Mood

Mood color choice helps to predict response to hypnotherapy in patients with irritable bowel syndrome. 📎

Abstract Title: Mood color choice helps to predict response to hypnotherapy in patients with irritable bowel syndrome. Abstract Source: BMC Complement Altern Med. 2010;10:75. Epub 2010 Dec 7. PMID: 21138549 Abstract Author(s): [No authors listed] Article Affiliation: Department of Medicine, University of Manchester, Manchester, UK. Abstract: BACKGROUND: Approximately two thirds of patients with irritable bowel syndrome (IBS) respond well to hypnotherapy. However, it is time consuming as well as expensive to provide and therefore a way of predicting outcome would be extremely useful. The use of imagery and color form an integral part of the hypnotherapeutic process and we have hypothesised that investigating color and how it relates to mood might help to predict response to treatment. In order to undertake this study we have previously developed and validated a method of presenting colors to individuals for research purposes called the Manchester Color Wheel (MCW). Using this instrument we have been able to classify colors into positive, neutral and negative shades and this study aimed to assess their predictive role in hypnotherapy. METHODS: 156 consecutive IBS patients (aged 14-74, mean 42.0 years, 127 (81%) females, 29 (19%) males) were studied. Before treatment, each patient was asked to relate their mood to a color on the MCW as well as completing the IBS Symptom Severity Score, the Hospital Anxiety and Depression (HAD) Scale, the Non-colonic Symptom Scale, the Quality of Life Scale and the Tellegen Absorption Scale (TAS) which is a measure of hypnotisability. Following hypnotherapy all these measures were repeated with the exception of the TAS. RESULTS: For patients with a positive mood color the odds of responding to hypnotherapy were nine times higher than that of those choosing either a neutral or negative color or no color at all (odds ratio: 8.889; p = 0.042). Furthermore, a high TAS score and the presence of HAD anxiety also had good predictive value (odds ratio: 4.024; p = 0.092, 3.917; p<0.001 respectively) with these markers and a positive mood color being independent of each other. In addition, these factors could be combined to give an even stronger prediction of outcome. Twice as many responders (63, 77.8%) had a positive mood color or were anxious or had a high TAS score compared with 32 (42.7%) without these factors (p<0.001). CONCLUSION: A positive mood color, especially when combined with HAD anxiety and a high TAS score, predict a good response to hypnotherapy. Article Published Date : Jan 01, 2010
Therapeutic Actions Positive Mood

NCBI pubmed

A longitudinal analysis of cannabis use and mental health symptoms among gay, bisexual, and other men who have sex with men in Vancouver, Canada.

Related Articles A longitudinal analysis of cannabis use and mental health symptoms among gay, bisexual, and other men who have sex with men in Vancouver, Canada. J Affect Disord. 2019 Jan 15;247:125-133 Authors: Chou FY, Armstrong HL, Wang L, Bacani N, Lachowsky NJ, Patterson TL, Walsh Z, Olarewaju G, Card KG, Roth EA, Hogg RS, Moore DM Abstract BACKGROUND: Cannabis use, anxiety, and depression are common among gay, bisexual, and other men who have sex with men (gbMSM) and some report using cannabis to manage mental health symptoms. METHODS: Sexually-active gbMSM aged ≥16 years were recruited into a longitudinal cohort through respondent-driven sampling and completed study visits every six months. Data on demographics, drug use, and anxiety and depression symptoms were collected via a self-administered computer-based survey. A study nurse determined previous mental health diagnoses and treatment. Using multivariable generalized linear mixed models, we examined factors associated with regular cannabis use (≥weekly in the previous 3 months) and, among individuals who reported anxiety or depression/bipolar diagnoses, factors associated with moderate/severe anxiety or depression symptoms. RESULTS: Of 774 participants (551 HIV-negative, 223 HIV-seropositive), 250 (32.3%) reported regular cannabis use, 200 (26.4%) reported ever being diagnosed with anxiety, and 299 (39.3%) reported ever being diagnosed with depression or bipolar disorder at baseline. Regular cannabis use was positively associated with HIV-seropositivity (aOR = 2.23, 95%CI:1.40-3.54) and previous mental health diagnosis (aOR = 1.52, 95%CI: 1.00-2.31, p = 0.05). Among those previously diagnosed with anxiety or depression/bipolar disorder, regular cannabis use was not associated with moderate/severe anxiety (aOR = 1.16, 95%CI:0.69-1.94) or depression symptoms (aOR = 0.96, 95%CI:0.59-1.58), respectively. LIMITATIONS: Because of observational study design, we are unable to determine absolute effect. CONCLUSIONS: Regular cannabis use was more likely among HIV-positive gbMSM and those previously diagnosed with a mental health disorder. No association was found between regular cannabis use and severity of anxious or depressive symptoms among those diagnosed with these conditions. PMID: 30665075 [PubMed - as supplied by publisher]

Effective connectivity within the ventromedial prefrontal cortex-hippocampus-amygdala network during the elaboration of emotional autobiographical memories.

Related Articles Effective connectivity within the ventromedial prefrontal cortex-hippocampus-amygdala network during the elaboration of emotional autobiographical memories. Neuroimage. 2019 Jan 18;: Authors: Nawa NE, Ando H Abstract Autobiographical memories (AMs) are often colored by emotions experienced during an event or those arising following further appraisals. However, how affective components of memories affect the brain-wide network recruited during the recollection of AMs remains largely unknown. Here, we examined effective connectivity during the elaboration of AMs - when retrieved episodic details are integrated to form a vivid construct - in the network composed by ventromedial prefrontal cortex (vmPFC), hippocampus and amygdala, three key regions associated with memory and affective processes. Functional MRI data was collected while volunteers recollected personal events of different types of valence and emotional intensity. Using dynamic causal modeling, we characterized the connections within the triadic network, and examined how they were modulated by the emotional intensity experienced during an event, and the valence of the affect evoked when recollecting the associated memory. Results primarily indicated the existence of a vmPFC to hippocampus effective connectivity during memory elaboration. Furthermore, the strength of the connectivity increased when participants relived memories of highly emotionally arousing events or that elicited stronger positive affect. These results indicate that the vmPFC drives hippocampal activity during memory elaboration, and plays a critical role in shaping affective responses that emanate from AMs. PMID: 30665009 [PubMed - as supplied by publisher]

A multimodal, naturalistic investigation of relationships between behavioral impulsivity, affect, and binge eating.

Related Articles A multimodal, naturalistic investigation of relationships between behavioral impulsivity, affect, and binge eating. Appetite. 2019 Jan 18;: Authors: Smith KE, Mason TB, Crosby RD, Engel SG, Wonderlich SA Abstract While binge eating is associated with both emotion regulation deficits and cognitive control impairments related to impulsivity, thus far research has not examined how dimensions of behavioral impulsivity may influence momentary relationships between affect and binge-eating episodes. The present study utilized multimodal methods to examine the extent to which individual differences in impulsive choice (i.e., delay and probabilistic discounting) and impulsive action (i.e., response inhibition) moderated momentary relationships between negative and positive affect (NA and PA) and binge eating measured in the natural environment. Participants were 30 adult women with binge-eating symptoms who completed measures of behavioral impulsivity (i.e., Monetary Choice Questionnaire, Cued Go/No-Go task, Game of Dice Task), followed by a 14-day ecological momentary assessment protocol during which they reported affect levels and binge-eating episodes. Results of generalized estimating equations indicated that greater delay discounting (i.e., preference for immediate, yet smaller rewards) strengthened momentary relationships between both PA and NA and binge eating. However, and unexpectedly, the relationship between momentary PA and binge eating was negative among individuals with greater Cued Go/No-go commission errors, suggesting that higher PA actually attenuated risk of binge episode occurring in these individuals. Together these findings highlight important distinctions between facets of behavioral impulsivity as well as their relationships with affect valence and intensity in predicting binge episodes. Specifically, temporal rather than probabilistic discounting may be most relevant to momentary processes that contribute to binge eating, and promotion of momentary positive affect may be helpful for individuals with poorer response inhibition. PMID: 30664909 [PubMed - as supplied by publisher]

Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats.

Related Articles Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats. Pharmacol Biochem Behav. 2019 Jan 18;: Authors: Randall PA, Fortino B, Huynh YW, Thompson BM, Larsen CE, Callen MP, Barrett ST, Murray JE, Bevins RA, Besheer J Abstract BACKGROUND: Smoking constitutes a significant public health risk. Alcohol and methamphetamine use disorders are also highly co-morbid with smoking, further increasing negative health outcomes. An important question in determining the underlying neurobiology of nicotine poly-drug use is understanding whether having a positive history with nicotine effects alters later drug-taking behavior. METHODS: The current experiments sought to elucidate whether having an appetitive nicotine conditioning history would affect later alcohol or methamphetamine self-administration. Adult male and female Long-Evans rats were first trained on a discriminated goal-tracking task in which the interoceptive effects of nicotine predicted sucrose reinforcement. As a control, pseudo-conditioned groups were included that had equated nicotine and sucrose experience. Rats were then shifted to either alcohol self-administration or methamphetamine self-administration. RESULTS: Nicotine conditioning history had no effect on acquisition or maintenance of alcohol self-administration in males or females. In contrast, an appetitive nicotine conditioning history decreased methamphetamine self-administration in female rats, but not males. CONCLUSIONS: In female, but not male rats, an appetitive conditioning history with nicotine decreases methamphetamine, but not alcohol, self-administration. This dissociation suggests that the effects may be due to a specific increase in the reinforcing value of methamphetamine. This may have implications for better understanding the progression of drug use from nicotine to methamphetamine. PMID: 30664897 [PubMed - as supplied by publisher]

Sexual Desire, Mood, Attachment Style, Impulsivity, and Self-Esteem as Predictive Factors for Addictive Cybersex.

Related Articles Sexual Desire, Mood, Attachment Style, Impulsivity, and Self-Esteem as Predictive Factors for Addictive Cybersex. JMIR Ment Health. 2019 Jan 21;6(1):e9978 Authors: Varfi N, Rothen S, Jasiowka K, Lepers T, Bianchi-Demicheli F, Khazaal Y Abstract BACKGROUND: An increasing number of studies are concerned with various aspects of cybersex addiction, the difficulty some persons have in limiting cybersex use despite a negative impact on everyday life. OBJECTIVE: The aim of this study was to assess potential links between the outcome variable cybersex addiction, assessed with the Compulsive Internet Use Scale (CIUS) adapted for cybersex use, and several psychological and psychopathological factors, including sexual desire, mood, attachment style, impulsivity, and self-esteem, by taking into account the age, sex, and sexual orientation of cybersex users. METHODS: A Web-based survey was conducted in which participants were assessed for sociodemographic variables and with the following instruments: CIUS adapted for cybersex use, Sexual Desire Inventory, and Short Depression-Happiness Scale. Moreover, attachment style was assessed with the Experiences in Close Relationships-Revised questionnaire (Anxiety and Avoidance subscales). Impulsivity was measured by using the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency Impulsive Behavior Scale. Global self-esteem was assessed with the 1-item Self-Esteem Scale. RESULTS: A sample of 145 subjects completed the study. Addictive cybersex use was associated with higher levels of sexual desire, depressive mood, avoidant attachment style, and male gender but not with impulsivity. CONCLUSIONS: Addictive cybersex use is a function of sexual desire, depressive mood, and avoidant attachment. PMID: 30664470 [PubMed]

Cognitive processes of emotional regulation, burnout and work engagement.

Related Articles Cognitive processes of emotional regulation, burnout and work engagement. Psicothema. 2019 Feb;31(1):73-80 Authors: Castellano E, Muñoz-Navarro R, Toledo MS, Spontón C, Medrano LA Abstract BACKGROUND: Workers constantly resort to cognitive processes of emotion regulation to deal with emotions they experience in the workplace. These processes belong either to the &ldquo;automatic&rdquo; (preconscious and fast) or the &ldquo;elaborative&rdquo; (conscious and slow) mode. This study aims to determine the role of these variables in the work setting and to analyze their relationship with positive and negative affect, engagement and burnout. METHOD: 350 employees (54.8% men and 45.2% women) were presented with several instruments measuring burnout, engagement, affect and cognitive emotion regulation strategies in a prospective study. An explanatory model was tested through structural equation modeling analysis. RESULTS: Acceptable fit indices and a significant explanatory value both for burnout (61%) and engagement (58%) were obtained. The use of &ldquo;automatic&rdquo; cognitive regulation strategies was associated with the presence of negative affect and burnout whereas &ldquo;elaborative&rdquo; processes were associated with positive affect and engagement. CONCLUSIONS: Our findings underscore the importance of the role of cognitive emotion regulation in organizational settings. PMID: 30664414 [PubMed - in process]

Type of memory and emotional valence in healthy aging, mild cognitive impairment, and Alzheimer's disease.

Related Articles Type of memory and emotional valence in healthy aging, mild cognitive impairment, and Alzheimer's disease. Psicothema. 2019 Feb;31(1):60-65 Authors: Meléndez JC, Escudero J, Satorres E, Pitarque A Abstract BACKGROUND: Autobiographical memory (AM) presents components related to the type of memory and may present an associated emotional valence. Comparing healthy older adults, adults with mild cognitive impairment (MCI), and adults with Alzheimer&acute;s disease (AD) gives contradictory results. We examined AM in these groups to analyze differences and provide information that would contribute to the understanding of AM and associated emotional deficits in patients. METHOD: 31 AD, 32 MCI, and 32 healthy older adults were evaluated using the Autobiographical Memory Test. Taking the number of memories elicited in each category as a dependent variable, an ANOVA of three groups &times; 3 types of valence was applied (positive, negative, neutral, intrasubject), and another ANOVA of 3 groups &times; 3 types of memory (specific, general, vague, intrasubject). RESULTS: specific-type responses are reduced with the progression of the pathology and in addition healthy subjects have a positive valence while AD presents a mainly neutral valence. CONCLUSIONS: Cognitive problems associated with aging tend to affect the highest level of AM specificity. Healthy subjects and MCI have memories with an emotional valence, whereas the AD group has a significant deterioration in these memories. PMID: 30664412 [PubMed - in process]

iRest Meditation for Older Adults with Depression Symptoms: 6-Month and 1-Year Follow-up.

Related Articles iRest Meditation for Older Adults with Depression Symptoms: 6-Month and 1-Year Follow-up. Int J Yoga Therap. 2019 Jan 21;: Authors: Wahbeh H, Fry N Abstract Preliminary positive evidence supports the use of iRest (Integrative Restoration) in older adults with depression symptoms. No long-term follow-up measures have been reported on whether the preliminary effects continue beyond initial iRest trainings. The growing population of older adults with depression symptoms is a serious public health issue, and effective interventions to support this vulnerable population are warranted. The objectives of this study were to evaluate the depression and depression-related symptoms 6 and 12 months after an iRest intervention. All study measures were collected online. Twenty-five of the original participants completed the 6- and 12-month surveys. Of those, nine stated that they still practiced the guided meditations at the time of the 12-month follow-up (five iRest and four vacation participants). Both groups had improvements in depression scores from baseline (week 0) to the 12-month follow-up. There were no differences between groups on depression symptoms or other measures except for negative mood and perceived stress, which were improved in the vacation group compared to the iRest group. Meditation practice was not a significant predictor of depression score improvement. PMID: 30664388 [PubMed - as supplied by publisher]

Cross-cultural adaptation and validation in the Italian population of the wolf motor function test in patients with stroke.

Related Articles Cross-cultural adaptation and validation in the Italian population of the wolf motor function test in patients with stroke. Funct Neurol. 2018 Oct/Dec;33(4):229-253 Authors: Berardi A, Dhrami L, Tofani M, Valente D, Sansoni J, Galeoto G Abstract Motor impairments of the upper extremities affect approximately 60% of stroke patients. Rehabilitation is extremely important and can make it possible to identify which manual function is causing difficulty for the patient and hindering daily activities. The Wolf Motor Function Test (WMFT) was recently highly recommended as one of several outcome measures that assess limitations of activities with a high level of psychometrics and clinical utility. The objective of this study was to translate and culturally adapt the WMFT for the Italian population (WMFT-IT) and examine its reliability and validity in Italian post-stroke adults with chronic hemiplegia or hemiparesis. The original scale was translated into Italian and culturally adapted in accordance with international guidelines. Its internal consistency and stability were examined using the Cronbach's alpha (α) coefficient and the intra-class correlation coefficient (ICC), respectively. Its concurrent validity was evaluated using the Pearson's correlation coefficient to compare the instrument with the Italian version of the Jebsen-Taylor Hand Function Test and the Disabilities of the Arm, Shoulder and Hand outcome measure. All WMFT-IT items were either identical or similar in meaning to the items in the original version. The WMFT-IT was administered to 24 subjects. Cronbach's α was 0.91 and 0.98 for the time and performance subscales respectively, and the ICC for test-retest reliability was 0.99. Pearson's correlation coefficients of the time subscale and the performance subscale both showed significant positive correlations (p <0.01). The WMFT-IT was found to be reliable and a valid outcome measure for assessing function and quality of movement of the upper extremities in post-stroke adults in the Italian population. PMID: 30663971 [PubMed - in process]

On Standardizing Within-Person Effects: Potential Problems of Global Standardization.

Related Articles On Standardizing Within-Person Effects: Potential Problems of Global Standardization. Multivariate Behav Res. 2019 Jan 20;:1-22 Authors: Wang L, Zhang Q, Maxwell SE, Bergeman CS Abstract Person-mean centering has been recommended for disaggregating between-person and within-person effects when modeling time-varying predictors. Multilevel modeling textbooks recommended global standardization for standardizing fixed effects. An aim of this study is to evaluate whether and when person-mean centering followed by global standardization can accurately estimate fixed-effects within-person relations (the estimand of interest in this study) in multilevel modeling. We analytically derived that global standardization generally yields inconsistent (asymptotically biased) estimates for the estimand when between-person differences in within-person standard deviations exist and the average within-person relation is nonzero. Alternatively, a person-mean-SD standardization (P-S) approach yields consistent estimates. Our simulation results further revealed (1) how misleading the results from global standardization were under various circumstances and (2) the P-S approach had accurate estimates and satisfactory coverage rates of fixed-effects within-person relations when the number of occasions is 30 or more (in many conditions, performance was satisfactory with 10 or 20 occasions). A daily diary data example, focused on emotional complexity, was used to empirically illustrate the approaches. Researchers should choose standardization approaches based on theoretical considerations and should clearly describe the purpose and procedure of standardization in research articles. Methodologists have emphasized the conceptual differences between between-person (BP) and within-person (WP) effects (e.g. Hamaker, 2012 ; Hamaker, Dolan, & Molenaar, 2005 ; Molenaar, 2004 ; Molenaar & Campbell, 2009 ) and the need to distinguish them and model both (e.g. Curran & Bauer, 2011 ; Hamaker, Kuiper, & Grasman, 2015 ; Wang & Maxwell, 2015 ). Using the effects of stress on positive affect as an example, a between-person effect refers to the extent to which people who are one unit above average on stress are above or below average on positive affect. In contrast, a within-person effect reflects the extent to which an individual has a higher or lower score on positive affect when he or she has a one unit higher score on stress. That is, between-person questions concern who, and within-person questions concern when. The two types of research questions are distinct, and the answer to one cannot generally be inferred from the other (e.g. Molenaar, 2004 ). PMID: 30663381 [PubMed - as supplied by publisher]

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single-arm trial.

Related Articles Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single-arm trial. J Hum Nutr Diet. 2019 Jan 21;: Authors: Buckland G, Travier N, Arribas L, Del Barco S, Pernas S, Zamora E, Bellet M, Cirauqui B, Margelí M, Muñoz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Valverde Y, Jansen E, Chajès V, Castro C, Agudo A Abstract BACKGROUND: The influence of nutrition on breast cancer prognosis is still inconclusive and therefore dietary interventions incorporating dietary biomarkers are needed to confirm compliance with dietary goals and clarify biological mechanisms. The present study assessed whether a lifestyle intervention in breast cancer survivors could affect dietary biomarkers of fruit and vegetables and fatty acids. METHODS: In this phase II single-arm trial, 37 overweight/obese early stage breast cancer patients completed a 12-week diet and exercise intervention. The intervention involved 1-h weekly diet sessions delivered by a dietician and 75-min bi-weekly physical activity sessions of moderate-to-high intensity led by trained monitors. Before and after the intervention, three 24-h dietary recalls were carried out to calculate nutrient intakes and, in addition, blood samples were taken to measure plasma carotenoids, vitamin E and retinol concentrations and erythrocyte membrane fatty acid (EFA) composition. Wilcoxon signed rank tests were used to assess changes in dietary and biomarkers measurements over the intervention period. RESULTS: After the intervention, there was a significant increase in the intake of dietary carotenoids (+15.1% compared to baseline) but not plasma carotenoids levels (+6.3%). Regarding the EFA levels, we observed a significant decrease in percentage of saturated fatty acids (-1.4%) and n-6 polyunsaturated fatty acids (-2.9%) and an increase in monounsaturated fatty acids (1.7%) and total and long-chain n-3 polyunsaturated fatty acids (by 13.1% and 13.7%, respectively). A favourable decrease in the ratio of long-chain n-6 to n-3 polyunsaturated fatty acids (-9.1%) was also observed. CONCLUSIONS: After a short-term diet and exercise intervention in overweight/obese breast cancer survivors, we observed significant changes in dietary nutrients and fatty acid biomarkers, suggesting positive dietary changes that could be relevant for breast cancer prognosis. PMID: 30663156 [PubMed - as supplied by publisher]

Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor.

Related Articles Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor. Mol Ther Oncolytics. 2019 Mar 29;12:16-25 Authors: Uchibori R, Teruya T, Ido H, Ohmine K, Sehara Y, Urabe M, Mizukami H, Mineno J, Ozawa K Abstract Adoptive transfer of T cells expressing a chimeric antigen receptor (CAR) is a promising cell-based anticancer therapy. Although clinical studies of this approach show therapeutic efficacy, additional genetic modification is necessary to enhance the efficacy and safety of CAR-T cells. For example, production of an antitumor cytokine from CAR-T cells can potentially enhance their tumor-killing activity, but there are concerns that constitutive expression of anticancer molecules will cause systemic side effects. Therefore, it is important that exogenous gene expression is confined to the tumor locality. Here, we aimed to develop an inducible promoter driven by activation signals from a CAR. Transgene expression in T cells transduced with the CD19-targeted CAR and an inducible promoter, including inducible reporter genes (CAR-T/iReporter), was only induced strongly by co-culture with CD19-positive target cells. CAR-T/iReporter cells also showed redirected cytolysis toward CD19-positive, but not CD19-negative, tumor cells. Overall, our study indicated that the inducible promoter was selectively driven by activation signals from the CAR, and transduction with the inducible promoter did not affect original effector activities including interleukin-2 and interferon-γ production and the antitumor activity of CAR-redirected cytotoxic T lymphocytes. Moreover, this inducible promoter permits visualization and quantification of the activation status in CAR-T cells. PMID: 30662937 [PubMed]

Obesity attenuates force-induced tooth movement in mice with the elevation of leptin level: a preliminary translational study.

Related Articles Obesity attenuates force-induced tooth movement in mice with the elevation of leptin level: a preliminary translational study. Am J Transl Res. 2018;10(12):4107-4118 Authors: Yan B, Liu D, Zhang C, Zhang T, Wang X, Yang R, Liu Y, He D, Zhou Y Abstract Increasing number of patients with high body-mass index (BMI) are encountered in the orthodontic clinic with the growing prevalence of obesity and overweight worldwide. Some clinical studies found that the rate of orthodontic tooth movement (OTM) in obese patients decreased. However, how obesity can impact OTM has not been determined yet. Here, we used the high-fat diet (HFD) induced obese mouse model to translate this clinical problem to the basic research, and back to exploring the potential clinical applications. C57BL/6J mice were fed with high-fat diet (HFD) for 5 weeks to induce obesity and orthodontic nickel-titanium springs were applied to the upper first molars to establish OTM model. The serum level of leptin was tested by ELISA. Mouse macrophage cell line RAW264.7 cells were used as osteoclast progenitor cells stimulated by sRANKL with the presence or absence of letpin in vitro. TRAP staining was used to detect osteoclasts. Leptin was administrated intraperitoneally in mice to determine whether it can affect OTM in vivo. In obese mice, we found that OTM was attenuated and the number of osteoclasts decreased with the elevated serum level of leptin. Mechanically, we confirmed that leptin inhibited osteoclastogenesis and osteoclast functional genes expression. To translate our findings back to potential applications, we then revealed the administration of leptin could decrease OTM in wild type mice along with the decreased number of TRAP-positive osteoclasts. Taken together, these results demonstrated that the elevated level of leptin in obese mice was able to inhibit osteoclastogenesis and decrease OTM. Administration of leptin could inhibit molar mesial movement and possessed the potential to be a clinical anchorage reinforcement method. PMID: 30662654 [PubMed]

The Human IL-23 Decoy Receptor Inhibits T-Cells Producing IL-17 by Genetically Engineered Mesenchymal Stem Cells.

Related Articles The Human IL-23 Decoy Receptor Inhibits T-Cells Producing IL-17 by Genetically Engineered Mesenchymal Stem Cells. Int J Cell Biol. 2018;2018:8213912 Authors: Rostami M, Haidari K, Shahbazi M Abstract The immunomodulatory and self-renewable features of human adipose mesenchymal stem cells (hAD-MSCs) mark their importance in regenerative medicine. Interleukin 23 (IL- 23) as a proinflammatory cytokine suppresses T regulatory cells (Treg) and promotes the response of T helper 17 (Th17) and T helper 1 (Th1) cells. This pathway starts inflammation and immunosuppression in several autoimmune diseases. The current study for producing recombinant IL- 23 decoy receptor (RIL- 23R) using hAD-MSCs as a good candidate for ex vivo cell-based gene therapy purposes reducing inflammation in autoimmune diseases. hAD-MSCs was isolated from lipoaspirate and then characterized by differentiation. RIL- 23R was designed and cloned into a pCDH-813A- 1 lentiviral vector. The transduction of hAD-MSCs was performed at MOI (multiplicity of infection) = 50 with pCDH- EFI α- RIL- 23R- PGK copGFP. Expressions of RIL- 23R and octamer-binding transcription factor 4 (OCT- 4) were determined by real-time polymerase chain reaction (real time-PCR). Self-renewing properties were assayed with OCT- 4. Bioactivity of the designed RIL- 23R was evaluated by IL- 17 and IL- 10 expression of mouse splenocytes. Cell differentiation confirmed the true isolation of hAD-MSCs from lipoaspirate. Restriction of the enzyme digestion and sequencing verified the successful cloning of RIL- 23R in the CD813A-1 lentiviral vector. The green fluorescent protein (GFP) positive transduction rate was up to 90%, and real-time PCR showed the expression level of RIL-23R. Oct-4 had a similar expression pattern with nontransduced hAD-MSCs and transduced hAD-MSCs/ RIL-23R indicating that lentiviral vector did not affect hAD-MSCs characteristics. Downregulation of IL-17 and upregulation of IL-10 showed the correct activity of the engineered hAD-MSCs. The results showed that the transduced hAD-MSCs/ RIL- 23R, expressing IL-23 decoy receptor, can give a useful approach for a basic research on cell-based gene therapy for autoimmune disorders. PMID: 30662466 [PubMed]

Shortening Fermentation Period and Quality Improvement of Fermented Fish, Chouguiyu, by Co-inoculation of Lactococcus lactis M10 and Weissella cibaria M3.

Related Articles Shortening Fermentation Period and Quality Improvement of Fermented Fish, Chouguiyu, by Co-inoculation of Lactococcus lactis M10 and Weissella cibaria M3. Front Microbiol. 2018;9:3003 Authors: Bao R, Liu S, Ji C, Liang H, Yang S, Yan X, Zhou Y, Lin X, Zhu B Abstract Chouguiyu, a Chinese traditional fermented fish, is famous for its uniquely strong odor and desirable taste. However, traditional spontaneous fermentation often resulted in contamination and unstable quality of products. In this study, individual or conjunctive inoculation of two indigenous lactic acid bacteria (LAB), Lactococcus lactis M10 and Weissella cibaria M3, was tested for their effect on improving Chouguiyu's quality. It was shown that inoculation would not affect the system's pH, while increased the total bacteria count and lactic acid bacteria amounts. Matrix-assisted laser desorption/ionization time-of-flight mass (MALDI-TOF) analysis results revealed that Lactoc. lactis M10 and W. cibaria M3 could quickly occupy a dominant position in the ecosystem, and Lactoc. lactis M10 played an important role in the control of spoilage bacteria. Volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), and biogenic amines results also showed that Lactoc. lactis M10 had a positive effect on improving the product's quality. Co-inoculation of Lactoc. lactis M10 and W. cibaria M3 could promote the formation of flavor according to the E-nose and gas chromatography-mass spectrometer (GC-MS) analyses, especially for the aroma-active and key volatile compounds. PCA plots of E-nose and hierarchical clustering analysis of GC-MS profiles revealed that the co-inoculation sample at the fifth day (LW5) was the most similar to the natural fermentation sample at the seventh day (C7). The overall acceptance of LW5 was also the closest to that of C7 in sensory evaluation. In conclusion, mixed starter culture was shown to have a good effect on improving product quality and enhancing flavor with fermentation time shortened by 29%. PMID: 30662432 [PubMed]

A Latent Profile Analysis of Affective Triggers for Risky and Impulsive Behavior.

Related Articles A Latent Profile Analysis of Affective Triggers for Risky and Impulsive Behavior. Front Psychol. 2018;9:2651 Authors: Kemp E, Sadeh N, Baskin-Sommers A Abstract Common theoretical models of risky and impulsive behaviors suggest that individuals engage in risky behavior to avoid negative affect or enhance positive affect. However, little research has been done to identify person-centered affective profiles of risky and impulsive behavior, and delineate the individual differences across these profiles. The present study used the Risky, Impulsive, and Self-destructive Behavior Questionnaire in community (N = 439) and incarcerated (N = 262) samples to examine latent affect profiles for risky and impulsive behavior. Four affective profiles emerged: low avoidance and low approach, average avoidance and average approach, high avoidance, and high approach. Conditional probability correlations revealed meaningful differences across these profiles in psychiatric symptomatology, personality characteristics, and behavior. Consideration of affective triggers provides an important framework for dissociating the underlying reasons why individuals engage in risky behavior. PMID: 30662421 [PubMed]

Characterizing Nature and Participant Experience in Studies of Nature Exposure for Positive Mental Health: An Integrative Review.

Related Articles Characterizing Nature and Participant Experience in Studies of Nature Exposure for Positive Mental Health: An Integrative Review. Front Psychol. 2018;9:2617 Authors: Barnes MR, Donahue ML, Keeler BL, Shorb CM, Mohtadi TZ, Shelby LJ Abstract A growing number of studies demonstrate significant associations between nature experiences and positive mental health outcomes (e.g., improved mood, decreased stress). However, implementation of this research by practitioners in fields such as urban design or public health has been limited. One reason for this is that it remains unclear what elements of nature and types of participant experience are consistently associated with mental health benefits. As a result, decision-makers who aim to enhance mental health in cities have little guidance about which elements of nature and types of experiences in natural areas may lead to positive mental health outcomes. We reviewed 30 studies with 41 distinct exposures in nature that elicited positive mental health benefits and characterized the elements of nature found at these sites, as well as aspects of participants' experience. Elements of natural areas considered include: forest, managed grass, and water as dominant land cover types, specific water features (e.g., small ponds, fountains) and built features (e.g., trails, paths). The majority of the studies we reviewed assessed the experiences of individuals (vs. in groups) participating in walks during warmer seasons. Most studies did not describe the "nature of the nature" associated with positive mental health outcomes. We contacted authors and used Google Earth imagery to reconstruct the specific natural elements, landscape typology, and site adjacencies present in past studies. We recommend specific ways researchers could better and more transparently document important elements of nature and participant experience in study design and reporting that will enhance the planning and design relevance of their work. PMID: 30662418 [PubMed]

Research on How Emotional Expressions of Emotional Labor Workers and Perception of Customer Feedbacks Affect Turnover Intentions: Emphasis on Moderating Effects of Emotional Intelligence.

Related Articles Research on How Emotional Expressions of Emotional Labor Workers and Perception of Customer Feedbacks Affect Turnover Intentions: Emphasis on Moderating Effects of Emotional Intelligence. Front Psychol. 2018;9:2526 Authors: Lee YH, Lee SHB, Chung JY Abstract Previous studies have used various external variables and parameters as well as moderator variables such as emotional intelligence have been to understand emotional labor and its related problems. However, a comprehensive model to study such variables' correlations with each other and their overall effect on emotional labor has not yet been established. This study used a structural equation model to understand the relationship between employees' expression of emotional labor and perception of customer feedbacks. The study also looked at how the perception of customer feedback affects emotional exhaustion in order to understand how emotional exhaustion affects job satisfaction and turnover intentions. Further, in order to fully understand the effects of emotion on emotional labor at the service contact points, this study developed and tested a model of emotional labor with four factors of emotional intelligence as moderating factors. Five hundred and seventy nine emotional labor workers in service industries in the United States were collected and 577 valid survey results have been analyzed. The result shows that there exists moderating effects of emotional intelligence on how employees' Deep Acting and Surface Acting recognize customers' reactions, both positive and negative, that would affect employees' Emotional Exhaustion and Job Satisfaction, and hence, Turnover Intention. The result suggests that employees with better understanding of their own emotions, although they are more likely to recover from emotional exhaustion, experience a greater negative effect when there is a discrepancy between what they feel and how they should act. PMID: 30662415 [PubMed]

Junctional Rhythm: A Rare Sign in Leptospirosis.

Related Articles Junctional Rhythm: A Rare Sign in Leptospirosis. Indian J Crit Care Med. 2018 Dec;22(12):889-891 Authors: Warrier R, Singh SK, Singh S, Tentu AK, Singh N, Dash C, Singh V Abstract Leptospirosis is an important re-emerging infectious disease. Leptospirosis has been estimated to affect tens of millions of humans annually with a case fatality rate ranging from 5% to 25%; however, it is underreported due to the lack of clinical suspicion and barriers to diagnostic capacity. A 33-year-old healthy male presented with a history of fever of 2-day duration. His examination revealed icterus. His workup did not show any significant findings except for a mild transaminitis and a rise in serum creatinine by 0.5 mg/dl. Later, the patient developed bradycardia. An ELISA test for Leptospira antibodies was positive. The patient recovered after a course of intravenous antibiotics. Leptospirosis should be considered early in the diagnosis of any patient who presents with acute, nonspecific febrile illness with multiorgan involvement. Our case had an atypical presentation with involvement of the cardiovascular system in the form of junctional rhythm. PMID: 30662232 [PubMed]

Cost-Utility Analysis Using EQ-5D-5L Data: Does How the Utilities Are Derived Matter?

Related Articles Cost-Utility Analysis Using EQ-5D-5L Data: Does How the Utilities Are Derived Matter? Value Health. 2019 Jan;22(1):45-49 Authors: Yang F, Devlin N, Luo N Abstract OBJECTIVES: To explore how the use of EQ-5D-5L value set and crosswalk from EQ-5D-5L to EQ-5D-3L (and use of 3L value set) would affect cost-effectiveness analysis results for England and six other countries (Canada, the Netherlands, China, Japan, South Korea, and Singapore). METHODS: Individual-level utilities derived from primary 5L data using both value set (5L) and crosswalk (c5L) approaches were applied to three Markov models assessing the cost-effectiveness of hemodialysis (HD) and peritoneal dialysis (PD) for end-stage renal disease (ESRD) patients to estimate incremental quality-adjusted life years (QALYs). The mathematic functions between incremental QALY and utility were derived. RESULTS: 5L- and c5L-based incremental QALYs were similar in the model for non-diabetic patients (range: 1.910-2.149, 1.922-2.121). 5L tends to generate more incremental QALYs than c5L in the model for diabetic patients (range: 1.454-1.633, 1.365-1.568) but fewer incremental QALYs in the model for all ESRD patients (range: 0.290-0.480, 0.315-0.493). In all models, 5L (c5L) generated more incremental QALYs when Chinese (South Korean) value sets were used. The largest and smallest differences in 5L- and c5L-based incremental QALYs were observed when Chinese and Dutch value sets were used. Incremental QALYs was a positive linear function of both utility of PD and difference in utilities of HD and PD. CONCLUSIONS: The value set and crosswalk approaches may not be used interchangeably in economic evaluation when EQ-5D-5L data are used to estimate utilities. Results of cost-effectiveness analysis using Markov models may be affected by both absolute utilities and their differences. PMID: 30661633 [PubMed - in process]
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