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Traditional Chinese Medicine

Traditional Chinese medicine (TCM; simplified Chinese: 中医; traditional Chinese: 中醫; pinyin: Zhōngyī) is a style of traditional medicine built on a foundation of more than 2,500 years of Chinese medical practice that includes various forms of herbal medicine, acupuncture, massage (tui na), exercise (qigong), and dietary therapy, but recently also influenced by modern Western medicine. TCM is widely used in Greater China (where it has long been the standard system of medicine), and is becoming increasingly popular and recognized worldwide (where it is primarily approached as alternative medicine).

One of the basic tenets of TCM is that "the body's vital energy (ch'i or qi) circulates through channels, called meridians, that have branches connected to bodily organs and functions." Concepts of the body and of disease used in TCM reflect its ancient origins and its emphasis on dynamic processes over material structure, similar to European humoral theory. Scientific investigation has not found histological or physiological evidence for traditional Chinese concepts such as qi, meridians, and acupuncture points. The TCM theory and practice are not based upon scientific knowledge, and there is disagreement between TCM practitioners on what diagnosis and treatments should be used for any given patient. The effectiveness of Chinese herbal medicine remains poorly researched and documented. There are concerns over a number of potentially toxic plants, animal parts, and mineral Chinese medicinals. There are also concerns over illegal trade and transport of endangered species including rhinoceroses and tigers, and the welfare of specially farmed animals including bears. A review of cost-effectiveness research for TCM found that studies had low levels of evidence, but so far have not shown benefit outcomes. Pharmaceutical research has explored the potential for creating new drugs from traditional remedies, with few successful results. A Nature editorial described TCM as "fraught with pseudoscience", and said that the most obvious reason it hasn't delivered many cures is that the majority of its treatments have no logical mechanism of action. Proponents propose that research has so far missed key features of the art of TCM, such as unknown interactions between various ingredients and complex interactive biological systems.

The doctrines of Chinese medicine are rooted in books such as the Yellow Emperor's Inner Canon and the Treatise on Cold Damage, as well as in cosmological notions such as yin-yang and the five phases. Starting in the 1950s, these precepts were standardized in the People's Republic of China, including attempts to integrate them with modern notions of anatomy and pathology. In the 1950s, the Chinese government promoted a systematized form of TCM.

While health is perceived as the harmonious interaction of these entities and the outside world, disease is interpreted as a disharmony in interaction. TCM diagnosis aims to trace symptoms to patterns of an underlying disharmony, by measuring the pulse, inspecting the tongue, skin, and eyes, and looking at the eating and sleeping habits of the person as well as many other things.

Traces of therapeutic activities in China date from the Shang dynasty (14th–11th centuries BCE). Though the Shang did not have a concept of "medicine" as distinct from other fields, their oracular inscriptions on bones and tortoise shells refer to illnesses that affected the Shang royal family: eye disorders, toothaches, bloated abdomen, etc., which Shang elites usually attributed to curses sent by their ancestors. There is no evidence that the Shang nobility used herbal remedies. According to a 2006 overview, the "Documentation of Chinese materia medica (CMM) dates back to around 1,100 BCE when only dozens of drugs were first described. By the end of the 16th century, the number of drugs documented had reached close to 1,900. And by the end of the last century, published records of CMM had reached 12,800 drugs."

Stone and bone needles found in ancient tombs led Joseph Needham to speculate that acupuncture might have been carried out in the Shang dynasty. This being said, most historians now make a distinction between medical lancing (or bloodletting) and acupuncture in the narrower sense of using metal needles to treat illnesses by stimulating specific points along circulation channels ("meridians") in accordance with theories related to the circulation of Qi. The earliest evidence for acupuncture in this sense dates to the second or first century BCE.

The Yellow Emperor's Inner Canon (Huang Di Nei Jing), the oldest received work of Chinese medical theory, was compiled around the first century BCE on the basis of shorter texts from different medical lineages. Written in the form of dialogues between the legendary Yellow Emperor and his ministers, it offers explanations on the relation between humans, their environment, and the cosmos, on the contents of the body, on human vitality and pathology, on the symptoms of illness, and on how to make diagnostic and therapeutic decisions in light of all these factors. Unlike earlier texts like Recipes for Fifty-Two Ailments, which was excavated in the 1970s from a tomb that had been sealed in 168 BCE, the Inner Canon rejected the influence of spirits and the use of magic It was also one of the first books in which the cosmological doctrines of Yinyang and the Five Phases were brought to a mature synthesis.

The Treatise on Cold Damage Disorders and Miscellaneous Illnesses (Shang Han Lun) was collated by Zhang Zhongjing sometime between 196 and 220 CE; at the end of the Han dynasty. Focusing on drug prescriptions rather than acupuncture, it was the first medical work to combine Yinyang and the Five Phases with drug therapy. This formulary was also the earliest public Chinese medical text to group symptoms into clinically useful "patterns" (zheng 證) that could serve as targets for therapy. Having gone through numerous changes over time, the formulary now circulates as two distinct books: the Treatise on Cold Damage Disorders and the Essential Prescriptions of the Golden Casket, which were edited separately in the eleventh century, under the Song dynasty.

In the centuries that followed, several shorter books tried to summarize or systematize its contents of the book Yellow Emperor's Inner Canon. The Canon of Problems (probably second century CE) tried to reconcile divergent doctrines from the Inner Canon and developed a complete medical system centered on needling therapy. The AB Canon of Acupuncture and Moxibustion (Zhenjiu jiayi jing 針灸甲乙經, compiled by Huangfu Mi sometime between 256 and 282 CE) assembled a consistent body of doctrines concerning acupuncture; whereas the Canon of the Pulse (Maijing 脈經; ca. 280) presented itself as a "comprehensive handbook of diagnostics and therapy."

In 1950, Chairman Mao Zedong made a speech in support of traditional Chinese medicine (TCM) which was influenced by political necessity. Mao believed he and the Chinese Communist Party should promote TCM but he did not personally believe in TCM and he did not use it. In 1952, the president of the Chinese Medical Association said that, "This One Medicine, will possess a basis in modern natural sciences, will have absorbed the ancient and the new, the Chinese and the foreign, all medical achievements—and will be China’s New Medicine!"

  • Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

    Abstract Title:

    Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

    Abstract Source:

    Antiviral Res. 2005 Jul ;67(1):18-23. PMID: 15885816

    Abstract Author(s):

    Shi-You Li, Cong Chen, Hai-Qing Zhang, Hai-Yan Guo, Hui Wang, Lin Wang, Xiang Zhang, Shi-Neng Hua, Jun Yu, Pei-Gen Xiao, Rong-Song Li, Xuehai Tan

    Article Affiliation:

    Shi-You Li

    Abstract:

    More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4 +/- 0.2 to 88.2 +/- 7.7 microg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7 +/- 1.2 nM. This compound has a CC50 value of 14980.0 +/- 912.0 nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.

  • Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

    Abstract Title:

    Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

    Abstract Source:

    Antiviral Res. 2005 Jul ;67(1):18-23. PMID: 15885816

    Abstract Author(s):

    Shi-You Li, Cong Chen, Hai-Qing Zhang, Hai-Yan Guo, Hui Wang, Lin Wang, Xiang Zhang, Shi-Neng Hua, Jun Yu, Pei-Gen Xiao, Rong-Song Li, Xuehai Tan

    Article Affiliation:

    Shi-You Li

    Abstract:

    More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4 +/- 0.2 to 88.2 +/- 7.7 microg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7 +/- 1.2 nM. This compound has a CC50 value of 14980.0 +/- 912.0 nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.

  • Integrated Chinese-western therapy versus western therapy alone on survival rate in patients with non-small-cell lung cancer at middle-late stage. 📎

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    Abstract Title:

    Integrated Chinese-western therapy versus western therapy alone on survival rate in patients with non-small-cell lung cancer at middle-late stage.

    Abstract Source:

    J Tradit Chin Med. 2013 Aug ;33(4):433-8. PMID: 24187861

    Abstract Author(s):

    Guoqiang Lin, Yingqiu Li, Shengxi Chen, Haihe Jiang

    Article Affiliation:

    Guoqiang Lin

    Abstract:

    OBJECTIVE:To compare the effects of integrated Chinese-Western therapy versus Western therapy alone on the survival rate of patients with non-small-cell lung cancer (NSCLC) at middle-late stage and to evaluate prognostic factors.

    METHODS:We selected 98 inpatients with middle-late stage NSCLC diagnosed from March 2009 to March 2011 and randomly divided them into two groups, with 49 cases in each group, and the clinical data were analyzed retrospectively. The control group was treated by the combined methods of Western Medicine, including chemotherapy, supportive treatment and symptomatic treatment. The observation group was treated by injection and prescriptions of Chinese medicine based on Traditional Chinese Medicine syndrome differentiation and by the same combined methods of western treatment used in the control group. After treatment, the survival rates of the patients were compared by the stage of cancer and evaluation of 24 prognostic factors analyzed by a Cox regression model, and the clinical data were statistically analyzed.

    RESULTS:The survival rates of all patients were over 90.0% at 1 and 3 months after treatment with no significant differences between the two groups (P>0.05); In the observation group the survival rates at 6 months and 1 year were 93.4% and 42.8%, respectively, being superior to 85.6% and 18.3% in the control group (P<0.05). The median survival time in the observation group was superior to the control group (P<0.05); The effects of 24 prognostic factors were significantly better in the observation group than in the control group (P<0.05).

    CONCLUSION:Integrated Chinese-western therapy can significantly improve the survival rate in patients with middle-late stage NSCLC and improve prognostic factors compared with western therapy alone.

  • JOURNALS

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  • Manipulative reduction for lumbar intervertebral disc herniation: a controlled clinical trial

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    Abstract Title:

    [Manipulative reduction for lumbar intervertebral disc herniation: a controlled clinical trial].

    Abstract Source:

    Zhongguo Gu Shang. 2008 Apr;21(4):273-5. PMID: 19102187

    Abstract Author(s):

    Wei-bin Zhang, Yu Cao, Yong-an Sun, Chun-sheng Wang, Ying Wang, Shi-long Dong, Guo-zhong Ren, Ying-xin Yang, Jing-zhong Zhang

    Article Affiliation:

    The Beifang Hospital of General Hospital of Shenyang Military Command, Shenyang 110032, Liaoning, China.

    Abstract:

    OBJECTIVE: To investigate the effects of manipulative reduction on pain and clinical curative effect in patients with lumbar intervertebral disc herniation. METHODS: Eleven thousands one hundred and twenty-eight patients with lumbar intervertebral disc herniation from our hospital were enrolled from November 1986 to June 2007. They were randomly divided into control group and treatment group. Patients of the control group received lumbar traction and various physiotherapies. Patients of the treatment group received manipulative reduction, besides the treatment in the control group. The treatment was performed once a day,ten times as a course. Curative effects were assessed three courses later. Pain was evaluated by visual analogue scale before and after the treatment. RESULTS: No significant difference in the score of visual analogue scale was found before the treatment in the two groups (P>0.05). As compared with the score before treatment,it was decreased by 4.73 points after treatment in the control group, and decreased by 6.37 points in the treatment group. The decrease was more significant in the treatment group than the control group (P<0.01). The healing rate was 47.28% and total effective rate was 96.37% in the control group; The healing rate was 73.44% and total effective rate was 98.61% in the treatment group (P<0.01). CONCLUSION: Manipulative reduction for lumbar intervertebral disc herniation can remarkably relieve lumbar pain and improve clinical curative effect.

  • Mechanism of shen qian gujing granule in the treatment of menorrhagia

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    Abstract Title:

    [Mechanism of shen qian gujing granule in the treatment of menorrhagia].

    Abstract Source:

    Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Dec ;12(12):730-3, 709. PMID: 1304842

    Abstract Author(s):

    H Q Xia, C J Li, J Yu

    Article Affiliation:

    Obstetrics and Gynecology Hospital, Shanghai Medical University.

    Abstract:

    Shen Qian Gujing Granule, a Chinese herbal preparation has shown its efficacy of 87.7% in treating menorrhagia. PGE2, PGE2 alpha, TXB2 and 6-Keto-PGF1 alpha levels were measured in the endometrium and menstrual blood of both normal menstrual women and patient with menorrhagia before and after the treatment. Local TXB2 values of endometrial and menstrual blood were significantly higher in menorrhagia patients than that in normal subjects (P<0.05). And the local PGE2 values were higher in patients accompanied with Qi Deficiency (P<0.05) and lower in patients without Qi Deficiency (P<0.05). After the treatment, the local TXB2, PGE2 levels normalized. It suggests that Shen Qian Gujing Granule had a biphasic regulation on local PG values which yields good results for menorrhagia. Some mechanism were discussed.

  • Observation of clinical curative effect of "oblique-pulling" maneuver in the treatment of lumbar intervertebral disc herniation

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    Abstract Title:

    [Observation of clinical curative effect of "oblique-pulling" maneuver in the treatment of lumbar intervertebral disc herniation].

    Abstract Source:

    Zhongguo Gu Shang. 2010 Feb;23(2):84-6. PMID: 20345024

    Abstract Author(s):

    Jun Zhang, Lei Han, Peng Wang, Dong Yu, Min Lu, Ding-kun Lin, Tie-bing Song, Jiang-hao Lin, Shu-chun Sun

    Article Affiliation:

    Wangjing Hospital of China Academy of Chinese Medicine Sciences, Beijing 100102, China.

    Abstract:

    OBJECTIVE: To evaluate the clinical curative effect of "oblique-pulling" maneuver in patients with lumbar intervertebral disc herniation (LIDH). METHODS: Sixty-five LIDH cases were randomly divided into experimental group and control group. In the experimental group 32 patients were treated by "oblique-pulling" maneuver, and 32 patients in the control group were treated by lumbar traction therapy. One case were excluded from the study and another one case were dropped from the study. After one course of treatment, the therapeutic effects of the two groups were compared quantitatively by using the JOA and VAS scores, including the improvement of signs, symptoms, living ability, and low back and leg pain. RESULTS: After one course of treatment, in the experimental group, 7 cases were controlled well, 16 cases were marked effect, 8 cases were effect, 1 case was no effect. In the control group, 4 cases were controlled well, 10 cases were marked effect, 13 cases were effect, 4 cases was no effect in control group. The clinical effective rate of the experimental group was 96.86%, which was higher than 87.10% of the control group (P<0.05). In the experimental group the scores of JOA and VAS were obviously improved after treatment (P<0.001) and the improvement was better than that of control group (P<0.01). CONCLUSION: The "oblique-pulling" maneuver has the characteristics of simple operation, repeatability, good efficiency, high safety.

  • SARS-CoV protease inhibitors design using virtual screening method from natural products libraries📎

    Abstract Title:

    SARS-CoV protease inhibitors design using virtual screening method from natural products libraries.

    Abstract Source:

    J Comput Chem. 2005 Apr 15 ;26(5):484-90. PMID: 15693056

    Abstract Author(s):

    Bing Liu, Jiaju Zhou

    Article Affiliation:

    Bing Liu

    Abstract:

    Two natural products databases, the marine natural products database (MNPD) and the traditional Chinese medicines database (TCMD), were used to find novel structures of potent SARS-CoV protease inhibitors through virtual screening. Before the procedure, the databases were filtered by Lipinski's ROF and Xu's extension rules. The results were analyzed by statistic methods to eliminate the bias in target-based database screening toward higher molecular weight compounds for enhancing the hit rate. Eighteen lead compounds were recommended by the screening procedure. They were useful for experimental scientists in prioritizing drug candidates and studying the interaction mechanism. The binding mechanism was also analyzed between the best screening compound and the SARS protein.

  • SARS-CoV protease inhibitors design using virtual screening method from natural products libraries📎

    Abstract Title:

    SARS-CoV protease inhibitors design using virtual screening method from natural products libraries.

    Abstract Source:

    J Comput Chem. 2005 Apr 15 ;26(5):484-90. PMID: 15693056

    Abstract Author(s):

    Bing Liu, Jiaju Zhou

    Article Affiliation:

    Bing Liu

    Abstract:

    Two natural products databases, the marine natural products database (MNPD) and the traditional Chinese medicines database (TCMD), were used to find novel structures of potent SARS-CoV protease inhibitors through virtual screening. Before the procedure, the databases were filtered by Lipinski's ROF and Xu's extension rules. The results were analyzed by statistic methods to eliminate the bias in target-based database screening toward higher molecular weight compounds for enhancing the hit rate. Eighteen lead compounds were recommended by the screening procedure. They were useful for experimental scientists in prioritizing drug candidates and studying the interaction mechanism. The binding mechanism was also analyzed between the best screening compound and the SARS protein.

  • Some research clues on Chinese herbal medicine for SARS prevention and treatment

    Abstract Title:

    [Some research clues on Chinese herbal medicine for SARS prevention and treatment].

    Abstract Source:

    Zhongguo Zhong Yao Za Zhi. 2003 Jun ;28(6):481-3. PMID: 15015319

    Abstract Author(s):

    Pei-gen Xiao, Yong-yan Wang, Hong-shan Chen

    Article Affiliation:

    Pei-gen Xiao

    Abstract:

    OBJECTIVE:To provide some research clues from Chinese herbal medicine for SARS prevention and treatment.

    METHOD:According to the experience and information, to select several perspective candidates from anti-SARS effective TCM prescriptions and drugs.

    RESULT:A list of Chinese herbal medicine and more than 14 botanical taxa could be served for further anti-SARS investigation.

    CONCLUSION:This investigation indicated that Chinese herbal medicine will be an important source for ant-SARS new drug searching.

  • Some research clues on Chinese herbal medicine for SARS prevention and treatment

    Abstract Title:

    [Some research clues on Chinese herbal medicine for SARS prevention and treatment].

    Abstract Source:

    Zhongguo Zhong Yao Za Zhi. 2003 Jun ;28(6):481-3. PMID: 15015319

    Abstract Author(s):

    Pei-gen Xiao, Yong-yan Wang, Hong-shan Chen

    Article Affiliation:

    Pei-gen Xiao

    Abstract:

    OBJECTIVE:To provide some research clues from Chinese herbal medicine for SARS prevention and treatment.

    METHOD:According to the experience and information, to select several perspective candidates from anti-SARS effective TCM prescriptions and drugs.

    RESULT:A list of Chinese herbal medicine and more than 14 botanical taxa could be served for further anti-SARS investigation.

    CONCLUSION:This investigation indicated that Chinese herbal medicine will be an important source for ant-SARS new drug searching.

  • Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS.

    Abstract Title:

    Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS.

    Abstract Source:

    Am J Chin Med. 2006 ;34(6):937-47. PMID: 17163583

    Abstract Author(s):

    Shao Li, Ruiqin Wang, Yulong Zhang, Xuegong Zhang, A Joseph Layon, Yanda Li, Mingzhe Chen

    Article Affiliation:

    Shao Li

    Abstract:

    Severe acute respiratory syndrome (SARS) is an infectious disease and some of its symptoms were clinically indistinguishable of those from similar diseases. This study aimed to find the symptom combinations associated with adverse outcome and the therapeutic effects in a cohort of patients with probable SARS retrospectively. In 2003, 123 SARS cases in Beijing were subjected to a strictly western medicine (WM) treatment, or a combined treatment (WM plus Herba houttuyniae injection, addition of individualized herbal treatments when necessary), of which 115 were followed till death or discharge; 8 were transferred and lost to follow-up. In both treatment groups, clinical manifestations were evaluated daily; development of signs and symptoms, and their possible relationship with outcome, were assessed. The relationships between these sign/symptom complexes and outcome under two treatment protocols were evaluated and differences were noted. Dynamic symptom combinations, dividing into the early, the medium-term and the durational symptom clusters, were identified as likely being related to the adverse outcomes of SARS (p<0.05, p<0.01). Compared with a strictly WM treatment, the combined treatment resulted in a longer hospital stay (p = 0.028), a non-statistically significant mortality rate decrease (combined treatment: 9.6% versus WM: 11.1%), and a significant improvement of arthralgia and myalgia (p<0.05) in the early symptom cluster. Additionally, the combined protocol improved arterial oxyhemoglobin saturation significantly at day 22 (p<0.05). In conclusion, the progress and outcome of SARS may be associated with specific temporal patterns of development in combination of several non-specific signs and symptom complexes, which are also helpful for evaluating the therapeutic effects on SARS patients.

  • Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS.

    Abstract Title:

    Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS.

    Abstract Source:

    Am J Chin Med. 2006 ;34(6):937-47. PMID: 17163583

    Abstract Author(s):

    Shao Li, Ruiqin Wang, Yulong Zhang, Xuegong Zhang, A Joseph Layon, Yanda Li, Mingzhe Chen

    Article Affiliation:

    Shao Li

    Abstract:

    Severe acute respiratory syndrome (SARS) is an infectious disease and some of its symptoms were clinically indistinguishable of those from similar diseases. This study aimed to find the symptom combinations associated with adverse outcome and the therapeutic effects in a cohort of patients with probable SARS retrospectively. In 2003, 123 SARS cases in Beijing were subjected to a strictly western medicine (WM) treatment, or a combined treatment (WM plus Herba houttuyniae injection, addition of individualized herbal treatments when necessary), of which 115 were followed till death or discharge; 8 were transferred and lost to follow-up. In both treatment groups, clinical manifestations were evaluated daily; development of signs and symptoms, and their possible relationship with outcome, were assessed. The relationships between these sign/symptom complexes and outcome under two treatment protocols were evaluated and differences were noted. Dynamic symptom combinations, dividing into the early, the medium-term and the durational symptom clusters, were identified as likely being related to the adverse outcomes of SARS (p<0.05, p<0.01). Compared with a strictly WM treatment, the combined treatment resulted in a longer hospital stay (p = 0.028), a non-statistically significant mortality rate decrease (combined treatment: 9.6% versus WM: 11.1%), and a significant improvement of arthralgia and myalgia (p<0.05) in the early symptom cluster. Additionally, the combined protocol improved arterial oxyhemoglobin saturation significantly at day 22 (p<0.05). In conclusion, the progress and outcome of SARS may be associated with specific temporal patterns of development in combination of several non-specific signs and symptom complexes, which are also helpful for evaluating the therapeutic effects on SARS patients.

  • Thinking on Clinical rational use of TCM injection in the treatment of novel coronavirus pneumonia (COVID-19)

    Abstract Title:

    [Thinking on Clinical rational use of TCM injection in the treatment of novel coronavirus pneumonia (COVID-19)].

    Abstract Source:

    Zhonghua Yi Xue Za Zhi. 2020 Mar 3 ;100(0):E016. Epub 2020 Mar 3. PMID: 32122113

    Abstract Author(s):

    Z F Wang, Y P Wang, H M Zhang, Y P Fan, C Lü, Y Y Wang

    Article Affiliation:

    Z F Wang

    Abstract:

    [n/a]

  • Traditional Chinese Medicine

  • Traditional Chinese Medicine

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    Traditional Chinese medicine (TCM; simplified Chinese: 中医; traditional Chinese: 中醫; pinyin: Zhōngyī) is a style of traditional medicine built on a foundation of more than 2,500 years of Chinese medical practice that includes various forms of herbal medicine, acupuncture, massage (tui na), exercise (qigong), and dietary therapy, but recently also influenced by modern Western medicine. TCM is widely used in Greater China (where it has long been the standard system of medicine), and is becoming increasingly popular and recognized worldwide (where it is primarily approached as alternative medicine).

    One of the basic tenets of TCM is that "the body's vital energy (ch'i or qi) circulates through channels, called meridians, that have branches connected to bodily organs and functions." Concepts of the body and of disease used in TCM reflect its ancient origins and its emphasis on dynamic processes over material structure, similar to European humoral theory. Scientific investigation has not found histological or physiological evidence for traditional Chinese concepts such as qi, meridians, and acupuncture points. The TCM theory and practice are not based upon scientific knowledge, and there is disagreement between TCM practitioners on what diagnosis and treatments should be used for any given patient. The effectiveness of Chinese herbal medicine remains poorly researched and documented. There are concerns over a number of potentially toxic plants, animal parts, and mineral Chinese medicinals. There are also concerns over illegal trade and transport of endangered species including rhinoceroses and tigers, and the welfare of specially farmed animals including bears. A review of cost-effectiveness research for TCM found that studies had low levels of evidence, but so far have not shown benefit outcomes. Pharmaceutical research has explored the potential for creating new drugs from traditional remedies, with few successful results. A Nature editorial described TCM as "fraught with pseudoscience", and said that the most obvious reason it hasn't delivered many cures is that the majority of its treatments have no logical mechanism of action. Proponents propose that research has so far missed key features of the art of TCM, such as unknown interactions between various ingredients and complex interactive biological systems.

    The doctrines of Chinese medicine are rooted in books such as the Yellow Emperor's Inner Canon and the Treatise on Cold Damage, as well as in cosmological notions such as yin-yang and the five phases. Starting in the 1950s, these precepts were standardized in the People's Republic of China, including attempts to integrate them with modern notions of anatomy and pathology. In the 1950s, the Chinese government promoted a systematized form of TCM.

    While health is perceived as the harmonious interaction of these entities and the outside world, disease is interpreted as a disharmony in interaction. TCM diagnosis aims to trace symptoms to patterns of an underlying disharmony, by measuring the pulse, inspecting the tongue, skin, and eyes, and looking at the eating and sleeping habits of the person as well as many other things.

  • Traditional Chinese medicine for COVID-19 treatment📎

    Abstract Title:

    Traditional Chinese medicine for COVID-19 treatment.

    Abstract Source:

    Pharmacol Res. 2020 Mar 4 ;155:104743. Epub 2020 Mar 4. PMID: 32145402

    Abstract Author(s):

    Jun-Ling Ren, Ai-Hua Zhang, Xi-Jun Wang

    Article Affiliation:

    Jun-Ling Ren

    Abstract:

    [n/a]

  • Traditional chinese medicine in cancer care: a review of controlled clinical studies published in chinese. 📎

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    Abstract Title:

    Traditional chinese medicine in cancer care: a review of controlled clinical studies published in chinese.

    Abstract Source:

    PLoS One. 2013 ;8(4):e60338. Epub 2013 Apr 3. PMID: 23560092

    Abstract Author(s):

    Xun Li, Guoyan Yang, Xinxue Li, Yan Zhang, Jingli Yang, Jiu Chang, Xiaoxuan Sun, Xiaoyun Zhou, Yu Guo, Yue Xu, Jianping Liu, Alan Bensoussan

    Article Affiliation:

    Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China ; Centre for Complementary Medicine Research (CompleMED), University of Western Sydney, Sydney, New South Wales, Australia.

    Abstract:

    BACKGROUND:Traditional Chinese medicine (TCM) has been widely applied for cancer care in China. There have been a large number of controlled clinical studies published in Chinese literature, yet no systematic searching and analysis has been done. This study summarizes the current evidence of controlled clinical studies of TCM for cancer.

    METHODS:We searched all the controlled clinical studies of TCM therapies for all kinds of cancers published in Chinese in four main Chinese electronic databases from their inception to November 2011. We bibliometrically analyzed the included studies and assessed the reporting quality.

    RESULTS:A total of 2964 reports (involving 253,434 cancer patients) including 2385 randomized controlled trials and 579 non-randomized controlled studies were included. The top seven cancer types treated were lung cancer, liver cancer, stomach cancer, breast cancer, esophagus cancer, colorectal cancer and nasopharyngeal cancer by both study numbers and case numbers. The majority of studies (72%) applied TCM therapy combined with conventional treatment, whilst fewer (28%) applied only TCM therapy in the experimental groups. Herbal medicine was the most frequently applied TCM therapy (2677 studies, 90.32%). The most frequently reported outcome was clinical symptom improvement (1667 studies, 56.24%) followed by biomarker indices (1270 studies, 42.85%), quality of life (1129 studies, 38.09%), chemo/radiotherapy induced side effects (1094 studies, 36.91%), tumor size (869 studies, 29.32%) and safety (547 studies, 18.45%). Completeness and adequacy of reporting appeared to improve with time.

    CONCLUSIONS:Data from controlled clinical studies of TCM therapies in cancer treatment is substantial, and different therapies are applied either as monotherapy or in combination with conventional medicine. Reporting of controlled clinical studies should be improved based on the CONSORT and TREND Statements in future. Further studies should address the most frequently used TCM therapy for common cancers and outcome measures should address survival, relapse/metastasis and quality of life.

  • Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2)📎

    Abstract Title:

    Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2).

    Abstract Source:

    J Integr Med. 2020 03 ;18(2):87-88. Epub 2020 Feb 19. PMID: 32122812

    Abstract Author(s):

    Chang-Quan Ling

    Article Affiliation:

    Chang-Quan Ling

    Abstract:

    [n/a]

  • Traditional Chinese Medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis. 📎

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    Abstract Title:

    Traditional Chinese Medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis.

    Abstract Source:

    J Exp Clin Cancer Res. 2009 ;28:112. Epub 2009 Aug 12. PMID: 19674474

    Abstract Author(s):

    Ping Wu, Jean Jacques Dugoua, Oghenowede Eyawo, Edward J Mills

    Article Affiliation:

    Shanghai Hospital #4, Shanghai, PR China. This email address is being protected from spambots. You need JavaScript enabled to view it.

    Abstract:

    BACKGROUND:Liver cancer is a common malignancy with a high mortality rate. Given the poor prognosis associated with this cancer, many patients seek additional therapies that may improve quality of life or survival. Several Traditional Chinese Medicines (TCM) have been evaluated in clinical trials, but little is known about them outside of China.

    METHODS:We searched independently and in duplicate 8 electronic databases, including 2 Chinese language databases, until February 2009. We included any randomized clinical trials (RCT) evaluating a TCM oral preparation for the treatment of hepatocellular cancers. We abstracted data on survival, tumor response, and performance scores. We conducted a random-effects meta-analysis and applied a meta-regression analysis.

    RESULTS:We included 45 RCTs (n = 3,236). All studies employed an active control group. In general, the reporting of methodological issues was poor. We analyzed data from 37 trials reporting on complete response effects score (Relative Risk [RR] of 1.26 (95 CI, 1.04-1.52, P = 0.01, I2 = 0%, P = 0.99). Products containing ginseng, astragalus and mylabris had a larger treatment effect (OR 1.34, 95% CI, 1.04-1.71, P = 0.01) than the pooled broad estimate, also the case for astragalus-based treatments (OR 1.35, 95% CI, 1.001-1.80. P = 0.048). We examined survival rates and pooled 15 studies reporting on 6 month outcomes (RR 1.10, 95% CI, 1.04-1.15, P =<0.0001, I2 = 0%, P = 0.60). This effect was consistent at other prospective dates, including 12 months (22 trials, RR 1.26, 95% CI, 1.17-1.36, P =<0.0001, I2 = 7%, P = 0.36), 24 months (15 trials, 1.72, 95% CI, 1.40-2.03, P =<0.0001, I2 = 0%, P = 0.75); and, at 36 months (8 trials, RR 2.40, 95% CI, 1.65-3.49, P =<0.0001, I2 = 0%, P = 0.62).

    LIMITATIONS:All included trials were conducted in China where emerging evidence suggests many RCTs are not, in fact, randomized. Publication bias may exist, favouring positive reports.

    CONCLUSION:Our meta-analysis displays compelling evidence of effectiveness for hepatocellular cancers that should be evaluated in high-quality and transparent clinical trials.

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