CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Frankincense

  • Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. 📎

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    Abstract Title:

    Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial.

    Abstract Source:

    Cancer. 2011 Aug 15 ;117(16):3788-95. Epub 2011 Feb 1. PMID: 21287538

    Abstract Author(s):

    Simon Kirste, Markus Treier, Sabine Jolie Wehrle, Gerhild Becker, Mona Abdel-Tawab, Kathleen Gerbeth, Martin Johannes Hug, Beate Lubrich, Anca-Ligia Grosu, Felix Momm

    Article Affiliation:

    Simon Kirste

    Abstract:

    BACKGROUND:Patients irradiated for brain tumors often suffer from cerebral edema and are usually treated with dexamethasone, which has various side effects. To investigate the activity of Boswellia serrata (BS) in radiotherapy-related edema, we conducted a prospective, randomized, placebo-controlled, double-blind, pilot trial.

    METHODS:Forty-four patients with primary or secondary malignant cerebral tumors were randomly assigned to radiotherapy plus either BS 4200 mg/day or placebo. The volume of cerebral edema in the T2-weighted magnetic resonance imaging (MRI) sequence was analyzed as a primary endpoint. Secondary endpoints were toxicity, cognitive function, quality of life, and the need for antiedematous (dexamethasone) medication. Blood samples were taken to analyze the serum concentration of boswellic acids (AKBA and KBA).

    RESULTS:Compared with baseline and if measured immediately after the end of radiotherapy and BS/placebo treatment, a reduction of cerebral edema of>75% was found in 60% of patients receiving BS and in 26% of patients receiving placebo (P = .023). These findings may be based on an additional antitumor effect. There were no severe adverse events in either group. In the BS group, 6 patients reported minor gastrointestinal discomfort. BS did not have a significant impact on quality of life or cognitive function. The dexamethasone dose during radiotherapy in both groups was not statistically different. Boswellic acids could be detected in patients' serum.

    CONCLUSIONS:BS significantly reduced cerebral edema measured by MRI in the study population. BS could potentially be steroid-sparing for patients receiving brain irradiation. Our findings will need to be further validated in larger studies.

    Article Published Date : Aug 14, 2011

  • Discovery of Bioactive Natural Products for the Treatment of Acute Respiratory Infections - An Integrated Approach. 📎

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    Abstract Title:

    Discovery of Bioactive Natural Products for the Treatment of Acute Respiratory Infections - An Integrated Approach.

    Abstract Source:

    Planta Med. 2018 Jul ;84(9-10):684-695. Epub 2018 Mar 19. PMID: 29554706

    Abstract Author(s):

    Ulrike Grienke, Christina E Mair, Johannes Kirchmair, Michaela Schmidtke, Judith M Rollinger

    Article Affiliation:

    Ulrike Grienke

    Abstract:

    In this work, an integrated approach for the identification of new antiviral agents from natural sources for the treatment of acute respiratory infections is presented. The approach comprises (i) the selection of starting material based on traditional knowledge, (ii) phenotypic screening of extracts for antiviral activity, and (iii) the implementation ofpredictions to identify antiviral compounds and derive the molecular mechanism underlying their biological activity. A variety of starting materials from plants and fungi was selected for the production of 162 extracts. These extracts were tested in cytopathic effect inhibition assays against influenza virus A/Hong Kong/68 (HK/68), rhinovirus A2 (RV-A2), and coxsackie virus B3 (CV-B3). All extracts were also evaluated regarding their cytotoxicity. At an ICthreshold of 50 µg/mL, 20, 11, and 14% of all tested extracts showed antiviral activity against HK/68, CV-B3, and RV-A2, respectively. Among all active extracts (n = 47), 68% showed antiviral activity against one of the investigated viruses, whereas 31% inhibited at least two viruses. Herein, we present a comprehensive dataset of probed extracts along with their antiviral activities and cytotoxicity. Application examples presented in this work illustrate the phytochemical workflow for the identification of antiviral natural compounds. We also discuss the challenges, pitfalls, and advantages of the integrated approach.

    Article Published Date : Jun 30, 2018

  • Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial📎

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    Abstract Title:

    Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial.

    Abstract Source:

    Evid Based Complement Alternat Med. 2016 ;2016:7896081. Epub 2016 Mar 13. PMID: 27034695

    Abstract Author(s):

    Seo Yeon Choi, Kyungsook Park

    Article Affiliation:

    Seo Yeon Choi

    Abstract:

    This study aimed to investigate the effects of aromatherapy oil inhalation on symptoms, quality of life, sleep quality, and fatigue level among adults with perennial allergic rhinitis (PAR). Fifty-four men and women aged between 20 and 60 were randomized to inhale aromatherapy oil containing essential oil from sandalwood, geranium, and Ravensara or almond oil (the placebo) for 5 minutes twice daily for 7 days. PAR symptoms determined by Total Nasal Symptom Score (TNSS), the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), sleep quality by Verran Synder-Halpern (VSH) scale, and fatigue level by Chalder Fatigue Scale (CFS) were assessed before and after intervention period. Compared with the placebo, the experimental group showed significant improvement in TNSS, especially in nasal obstruction. The aromatherapy group also showed significantly higher improvements in total score of RQLQ and CFS. These findings indicate that inhalation of certain aromatherapy oil helps relieve PAR symptoms, improve rhinitis-specific quality of life, and reduce fatigue in patients with PAR. In conclusion, inhalation of aromatherapy essential oil may have potential as an effective intervention to alleviate PAR.

    Article Published Date : Dec 31, 2015

  • Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer

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    Abstract Title:

    [Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer].

    Abstract Source:

    Taehan Kanho Hakhoe Chi. 2008 Aug ;38(4):493-502. PMID: 18753801

    Abstract Author(s):

    So Young Chang

    Article Affiliation:

    Department of Nursing, Keimyung University, Jung-gu, Daegu, Korea. This email address is being protected from spambots. You need JavaScript enabled to view it.

    Abstract:

    PURPOSE:The purpose of this study was to examine the effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer.

    METHODS:This study was a nonequivalent control group pretest-posttest design. The subjects were 58 hospice patients with terminal cancer who were hospitalized. Twenty eight hospice patients with terminal cancer were assigned to the experimental group (aroma hand massage), and 30 hospice patients with terminal cancer were assigned to the control group (general oil hand massage). As for the experimental treatment, the experimental group went through aroma hand massage on each hand for 5 min for 7 days with blended oil-a mixture of Bergamot, Lavender, and Frankincense in the ratio of 1:1:1, which was diluted 1.5% with sweet almond carrier oil 50 ml. The control group went through general oil hand massage by only sweet almond carrier oil-on each hand for 5 min for 7 days.

    RESULTS:The aroma hand massage experimental group showed more significant differences in the changes of pain score (t=-3.52, p=.001) and depression (t=-8.99, p=.000) than the control group.

    CONCLUSION:Aroma hand massage had a positive effect on pain and depression in hospice patients with terminal cancer.

    Article Published Date : Jul 31, 2008

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