CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Flame Retardants

  • Dietary exposure to brominated flame retardants and abnormal Pap test results📎

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    Abstract Title:

    Dietary exposure to brominated flame retardants and abnormal Pap test results.

    Abstract Source:

    J Womens Health (Larchmt). 2011 Sep ;20(9):1269-78. Epub 2011 Jul 28. PMID: 21797757

    Abstract Author(s):

    Denise J Jamieson, Metrecia L Terrell, Nnenna N Aguocha, Chanley M Small, Lorraine L Cameron, Michele Marcus

    Article Affiliation:

    Denise J Jamieson

    Abstract:

    OBJECTIVE:This study examined a possible association of dietary exposure to polybrominated biphenyls (PBBs), a brominated flame retardant, and self-reported abnormal Pap test results and cervical dysplasia as a precursor to cervical cancer.

    METHODS:Women in Michigan who ingested contaminated poultry, beef, and dairy products in the early 1970s were enrolled in a population-based cohort study in Michigan. Serum PBB and serum polychlorinated biphenyl (PCB) concentrations were measured. Reproductive history and health information, including Pap test results, were self-reported by participants.

    RESULTS:Of the women, 23% (223 of 956) reported an abnormal Pap test. In unadjusted analyses, self-reporting an abnormal Pap test was associated with younger age, current smoking (hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.19-2.17), and longer duration of lifetime use of oral contraceptives (≥10 years; HR 1.92, 95% CI 1.21-3.06). When adjusting for PCB exposure, age at the interview, and smoking history, there was a slightly elevated risk of self-reporting an abnormal Pap test among the highly exposed women compared to women with nondetectable PBB concentrations (PBB≥13 μg/L, HR1.23, 95% CI 0.74-2.06); however, the CI was imprecise. When breastfeeding duration after the initial PBB measurement was taken into account, there was a reduced risk of self-reporting an abnormal Pap test among the highly exposed women who breastfed for ≥12 months (HR 0.41, 95% CI 0.06-3.03; referent group: women with nondetectable PBB concentrations who did not breastfeed).

    CONCLUSIONS:It remains important to evaluate the potential reproductive health consequences of this class of chemicals as well as other potential predictors of abnormal Pap tests.

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