CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Aloe Vera

Aloe vera (/ˈæloʊiː/ or /ˈæloʊ/) is a succulent plant species of the genus Aloe. An evergreen perennial, it originates from the Arabian Peninsula but grows wild in tropical climates around the world and is cultivated for agricultural and medicinal uses. The species is also used for decorative purposes and grows successfully indoors as a potted plant.

It is found in many consumer products including beverages, skin lotion, cosmetics, or ointments for minor burns and sunburns. There is little scientific evidence of the effectiveness or safety of Aloe vera extracts for either cosmetic or medicinal purposes. Studies finding positive evidence are frequently contradicted by other studies.

  • Aloe Vera

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    Aloe vera (/ˈæloʊiː/ or /ˈæloʊ/) is a succulent plant species of the genus Aloe. An evergreen perennial, it originates from the Arabian Peninsula but grows wild in tropical climates around the world and is cultivated for agricultural and medicinal uses. The species is also used for decorative purposes and grows successfully indoors as a potted plant.

  • Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway. 📎

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    Abstract Title:

    Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway.

    Abstract Source:

    Oncol Rep. 2016 Mar 24. Epub 2016 Mar 24. PMID: 27035222

    Abstract Author(s):

    Pinghua Tu, Qiu Huang, Yunsheng Ou, Xing Du, Kaiting Li, Yong Tao, Hang Yin

    Article Affiliation:

    Pinghua Tu

    Abstract:

    The present study was carried out to investigate the effect and mechanisms of aloe‑emodin (AE)-mediated photodynamic therapy (AE-PDT) on the human osteosarcoma cell line MG-63. After treatment with AE-PDT, the human osteosarcoma cell line MG-63 was tested for levels of viability, autophagy, reactive oxygen species (ROS) and apoptosis and changes in cell morphology with the CellCounting Kit-8 (CCK‑8), monodansylcadaverine (MDC) and Hoechst staining and transmission electron microscopy. The expression of proteins including LC-3, cleaved caspase-3, Beclin-1, Bcl-2, p-JNK, t-JNK and β-actin was examined with western blotting. AE-PDT significantly inhibited the viability of the MG-63 cells in an AE-concentration- and PDT energy density-dependent manner. Autophagy and apoptosis of MG-63 cells was substantially promoted in the AE-PDT group compared to the control group, the AE alone group and the light emitting diode (LED) alone group. Inhibition of autophagy by 3-methyladenine (3-MA) (5 mM) and chloroquine (CQ) (15 µM) significantly promoted the apoptosis rate and improved the sensitivity of the MG-63 cells to AE-PDT. AE-PDT was found to induce the expression of ROS and p-JNK. ROS scavenger, N-acetyl-L-cysteine (NAC, 5 mM), was able to hinder the autophagy,apoptosis and phosphorylation of JNK, and JNK inhibitor (SP600125, 10 µM) significantly inhibited the autophagy and apoptosis, and attenuated the sensitivity of MG63 cells to AE-PDT. In conclusion, AE-PDT induced the autophagy and apoptosis of human osteosarcoma cell line MG-63 through the activation of the ROS-JNK signaling pathway. Autophagy may play a protective role during the early stage following treatment of AE-PDT.

  • Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway. 📎

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    Abstract Title:

    Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway.

    Abstract Source:

    Oncol Rep. 2016 Mar 24. Epub 2016 Mar 24. PMID: 27035222

    Abstract Author(s):

    Pinghua Tu, Qiu Huang, Yunsheng Ou, Xing Du, Kaiting Li, Yong Tao, Hang Yin

    Article Affiliation:

    Pinghua Tu

    Abstract:

    The present study was carried out to investigate the effect and mechanisms of aloe‑emodin (AE)-mediated photodynamic therapy (AE-PDT) on the human osteosarcoma cell line MG-63. After treatment with AE-PDT, the human osteosarcoma cell line MG-63 was tested for levels of viability, autophagy, reactive oxygen species (ROS) and apoptosis and changes in cell morphology with the CellCounting Kit-8 (CCK‑8), monodansylcadaverine (MDC) and Hoechst staining and transmission electron microscopy. The expression of proteins including LC-3, cleaved caspase-3, Beclin-1, Bcl-2, p-JNK, t-JNK and β-actin was examined with western blotting. AE-PDT significantly inhibited the viability of the MG-63 cells in an AE-concentration- and PDT energy density-dependent manner. Autophagy and apoptosis of MG-63 cells was substantially promoted in the AE-PDT group compared to the control group, the AE alone group and the light emitting diode (LED) alone group. Inhibition of autophagy by 3-methyladenine (3-MA) (5 mM) and chloroquine (CQ) (15 µM) significantly promoted the apoptosis rate and improved the sensitivity of the MG-63 cells to AE-PDT. AE-PDT was found to induce the expression of ROS and p-JNK. ROS scavenger, N-acetyl-L-cysteine (NAC, 5 mM), was able to hinder the autophagy,apoptosis and phosphorylation of JNK, and JNK inhibitor (SP600125, 10 µM) significantly inhibited the autophagy and apoptosis, and attenuated the sensitivity of MG63 cells to AE-PDT. In conclusion, AE-PDT induced the autophagy and apoptosis of human osteosarcoma cell line MG-63 through the activation of the ROS-JNK signaling pathway. Autophagy may play a protective role during the early stage following treatment of AE-PDT.

  • Effectiveness of Aloe Vera and Antioxidant along with Physiotherapy in the Management of Oral Submucous Fibrosis.

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    Abstract Title:

    Effectiveness of Aloe Vera and Antioxidant along with Physiotherapy in the Management of Oral Submucous Fibrosis.

    Abstract Source:

    J Contemp Dent Pract. 2016 ;17(1):78-84. Epub 2016 Jan 1. PMID: 27084867

    Abstract Author(s):

    Nisha Singh, Manjula Hebbale, Amit Mhapuskar, Shams Ul Nisa, Shameeka Thopte, Saumya Singh

    Article Affiliation:

    Nisha Singh

    Abstract:

    BACKGROUND:Oral submucous fibrosis (OSMF) is a well-established precancerous condition affecting the oral mucosa. It is a disease that causes significant morbidity (in terms of loss of mouth function as tissues become rigid and mouth opening becomes difficult) and mortality (when transformation into squamous cell carcinoma occurs).

    AIM:The aim of the study is to compare the efficacy of Aloe vera with antioxidant when given along with physiotherapy in the management of OSMF.

    MATERIALS AND METHODS:Forty patients presenting with clinical signs and symptoms of OSMF were included for the study after informed consent. Group A included 20 patients who received Aloe vera gel (forever living gel) along with physiotherapy. Group B included 20 patients who received antioxidant capsules twice daily for 3 months along with physiotherapy exercises four times in a day. The following parameters, that is, burning sensation, mouth opening, tongue protrusion and cheek flexibility were recorded at each visit.

    RESULTS:Majority of the participant enrolled were in the age range of 30 to 35 years. Improvement in all the parameters was seen with the individuals receiving Aloe vera gel in comparison to antioxidants.

    CONCLUSION:So, Aloe vera being a soothing, simple and safe mode of treatment along with proper habit restriction can be considered to be an effectual protocol in the management of OSMF. The analgesic effects of Aloe vera with the physiotherapy exercises provide better results in reducing burning sensation and improving mouth opening, tongue protrusion and cheek flexibility in comparison to antioxidants.

  • Exploring a novel target treatment on breast cancer: aloe-emodin mediated photodynamic therapy induced cell apoptosis and inhibited cell metastasis.

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    Abstract Title:

    Exploring a novel target treatment on breast cancer: aloe-emodin mediated photodynamic therapy induced cell apoptosis and inhibited cell metastasis.

    Abstract Source:

    Anticancer Agents Med Chem. 2015 Aug 20. Epub 2015 Aug 20. PMID: 26295333

    Abstract Author(s):

    Qing Chena, Si Tiana, Jing Zhub, Kai-Ting Lia, Ting-He Yuc, Le-Hua Yub, Ding-Qun Bai

    Article Affiliation:

    Qing Chena

    Abstract:

    Photodynamic therapy (PDT), as a clinical cancer therapy, is a mild therapy, which involves application of photosensitizers (PSs) which located in target cells and then be irradiated by corresponding wawelength. The activation of PSs generates radical oxygenspecies ( ROS) to exert a selective cytotoxic activity for the target cells. Aloeemodin (AE) has been found to be a anti-tumor agent in many studies, and it also demonstrated to be a photosensitizer in recent years. In order to study the mechanism of aloe-emodin as a photosensitizer. In the present study, we investigated the mechanisms of photo-cytotoxicity induced by aloe-emodin in breast cancer MCF-7 cells. Analysis of cell proliferation evidenced that there was a dramatically depression after photodynamic treatment with aseries of aloe-emodin concentration and light doses showed. We observed changes apoptosis and demonstrated that the mechanisms of apoptosis were involved of mitochondrial and endoplasmic reticulum death pathway. The capacity of adhesion, migration and invasion of breast cells were measured usingWST8 and transwell assay and demonstrated that AE-PDT significantly inhibited adhesion, migration and invasion of MCF-7cells. The expression of MMP2, MMP9, VEGF and Nrf2 demonstrated that the metastasis was related to oxidative stress. Analysis of changes in cytoskeleton components (F-actin) evidenced cytoskeleton disorganization after treatment with AE-PDT. Taken together, the present results indicated that PDT with aloe emodin effectively suppressed cancer development in MCF-7cells, suggesting the potential of AE as one new photosensitizer in PDT can provide a new modility for treating cancer.

  • Exploring a novel target treatment on breast cancer: aloe-emodin mediated photodynamic therapy induced cell apoptosis and inhibited cell metastasis.

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    Abstract Title:

    Exploring a novel target treatment on breast cancer: aloe-emodin mediated photodynamic therapy induced cell apoptosis and inhibited cell metastasis.

    Abstract Source:

    Anticancer Agents Med Chem. 2015 Aug 20. Epub 2015 Aug 20. PMID: 26295333

    Abstract Author(s):

    Qing Chena, Si Tiana, Jing Zhub, Kai-Ting Lia, Ting-He Yuc, Le-Hua Yub, Ding-Qun Bai

    Article Affiliation:

    Qing Chena

    Abstract:

    Photodynamic therapy (PDT), as a clinical cancer therapy, is a mild therapy, which involves application of photosensitizers (PSs) which located in target cells and then be irradiated by corresponding wawelength. The activation of PSs generates radical oxygenspecies ( ROS) to exert a selective cytotoxic activity for the target cells. Aloeemodin (AE) has been found to be a anti-tumor agent in many studies, and it also demonstrated to be a photosensitizer in recent years. In order to study the mechanism of aloe-emodin as a photosensitizer. In the present study, we investigated the mechanisms of photo-cytotoxicity induced by aloe-emodin in breast cancer MCF-7 cells. Analysis of cell proliferation evidenced that there was a dramatically depression after photodynamic treatment with aseries of aloe-emodin concentration and light doses showed. We observed changes apoptosis and demonstrated that the mechanisms of apoptosis were involved of mitochondrial and endoplasmic reticulum death pathway. The capacity of adhesion, migration and invasion of breast cells were measured usingWST8 and transwell assay and demonstrated that AE-PDT significantly inhibited adhesion, migration and invasion of MCF-7cells. The expression of MMP2, MMP9, VEGF and Nrf2 demonstrated that the metastasis was related to oxidative stress. Analysis of changes in cytoskeleton components (F-actin) evidenced cytoskeleton disorganization after treatment with AE-PDT. Taken together, the present results indicated that PDT with aloe emodin effectively suppressed cancer development in MCF-7cells, suggesting the potential of AE as one new photosensitizer in PDT can provide a new modility for treating cancer.

  • The Ancient ‘Plant of Immortality’ That Treats Over 50 Medical Conditions

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    images/external-images/e5cb79c079395ea26a5931499c4b0a13.jpgKnown as “the plant of immortality” by the Ancient Egyptians, and treasured by numerous subsequent cultures, aloe vera it still known today for its many health benefits. For millennia it has been used to treat more than 50 medical conditions, from obesity to burns, dermatitis, ulcers, asthma, diabetes,  acne, and even leprosy.

     


     

    images/external-images/3f91f78b43e71db0dcb9713d3149e0c8.jpgAloe Vera is approximately 95% water, but the other 5% is made up of extremely high levels of healthy enzymes. The very special plant has more than 200 bioactive compounds such as minerals, enzymes, vitamins, amino acids, and polysaccharides, which all improve nutrient absorption in the body. It is also rich in calcium, iron, zinc, magnesium, copper, potassium, and manganese. It boasts anti-inflammatory and antibacterial properties which help detoxify the body and support the immune system. It also contains the vitamin B12, which is normally only found in animal based foods and it is important in the creation of new red blood cells, making it invaluable to vegetarians. It is native to Africa and parts of the Middle East, but can be grown in any home, making it accessible to anyone. It once was, and still remains, one of the world’s most popular and widely used remedies.

     


    images/external-images/e2172c1260f90fae75fb258ea6fd0046.jpgThe earliest known use of the aloe vera plant dates back 6,000 years to the Ancient Egyptians. The plant was known to hold the secrets to beauty, health, and immortality, hence it was known as “the plant of immortality.” Both Cleopatra and Nefertiti were known to use and value the juice of the plant as part of their daily beauty routines. Even the dead were embalmed with aloe vera due to its anti-bacterial and anti-fungal properties. This was important because the Ancient Egyptians believed that stopping the physical decomposition process would lead to eternal life. Along with embalming the dead, aloe would be given as a gift to the deceased pharaohs at their funeral ceremonies. A man’s wealth and esteem for the pharaoh were shown by the amount of aloe, in pounds, that he brought as an offering.

     


    images/external-images/b2febbf33985193a9f4a14db90284b7e.jpgFound in Thebes in 1858, the “papyrus of Eber” from 1,550 BCE, the time of Amen-Hotep, document the anti-inflammatory and pain soothing properties of the plant. The Mahometans of Egypt thought of aloe vera as a religious symbol. They believed that the holy symbol of the plant hanging in a doorway would protect them from slander and evil influences. The Egyptians also used the plant in the production of papyrus and as a treatment for tuberculosis. Similarly, documentation about aloe vera was found on clay boards from Nippur which date back to 2,200 BCE. At this time, the Ancient Mesopotamians were using the plant as a body detoxifier, as illness was seen as demonic possession and the divine plant used its natural powers to expel the demons.

     


    images/external-images/ce93f1a5769e02d55b2edfe5c595d867.jpgIn the time of Alexander the Great, aloe was also being used as a medicinal treatment. It has been documented that Alexander used aloe juice to heal the wounds of his warriors on the battlefield. He even went as far as having transportable carts of the plant in order to have fresh supplies at the ready during his battle campaigns. It is said that Aristotle convinced Alexander to capture the Island Socotra specifically to gain possession of the aloe groves therein.

     


    During the reign of Nero, in the 1st century AD, the physician and naturalist Dioscorides journeyed with the Roman armies in search of new methods of healing. He wrote several books, the first of which was “De Materia Medica” in 41-68 AD, teaching pharmaceutics, which included prescriptions and treatments for numerous illnesses. In a chapter on plant therapy, he describes aloe vera as one of his favourite healing plants. He recommends that the juice of the plant be used for numerous physical disorders such as the treatment of wounds, gastrointestinal discomfort, gingivitis, arthralgia, skin irritation, sunburn, acne, hair loss, and many more. Pliny the Elder, a contemporary physician, confirmed in his “Natural History, the discoveries of Dioscorides, but included the healing of leprosy sores and anti-perspirant to the list of aloe’s uses.


    In Chinese culture aloe was also seen as an important medical ingredient since the times of Marco Polo’s expeditions. In China, the dried juice of the aloe vera plant is know as “Lu-hui,” meaning “black deposit,” and was first mentioned in the 11th century. The treatment book of Shi-Shen describes the plant as the “Method of Harmony,” as such the plant played a major role in Chinese everyday life. In Japan, it was known as “the royal plant,” and the juice was consumed as an elixir or rubbed on the wounds of the samurai to heal them, in the same way as Alexander the Great.


    images/external-images/88edc2ecac7d1ac40f7c204000baf64a.jpgIn the 16th century, Spanish Jewish monks harvested aloe and were known to spread the plant to areas in which it had not been previously cultivated. These monks came to be renown as well educated phytologists and healers. At the same time, Christopher Columbus was known to have aloe vera growing in potted plants on his ships, using the gel from the plant to heal the wounds of his mercenaries. In fact, Christopher Columbus once said, “Four vegetables are indispensable for the well being of man: Wheat, the grape, the olive, and aloe. The first nourishes, the second raises the spirit, the third brings him harmony, and the fourth cures him.” Meanwhile, in the new world, the Native tribes also became familiar with the aloe vera plant. It became one of the 16 holy plants which were worshipped by specific tribes. Diluted aloe juice could be applied to the skin as an insect repellent on humans or on wood and other valuable materials, this treatment of preservation, much like the Egyptians embalming their dead, worked extremely well.

     


    During the crusades, the Knights Templar created a drink of palm wine, aloe pulp and hemp, which they named the “Elixir of Jerusalem,” and they believed that the drink could add years to their lives. Records from the 17th century show that the East India Trading Company purchased aloe from Socotra and Zanzibar. At this time, the West Indies became an important commercial region for aloe vera that was to be sold to the European market. Contemporaneously, the Dutch established aloe vera plantations in Barbados, Curacao, Aruba, and Bonaire. By the 18th century large amounts of aloe were being imported to be made into medicines. From that time to today, aloe has remained one of the most popular medicines, topical lotions, and natural health products on the market.


     

    Resources

    Medicinal Plants of Ancient. Available at: https://www.aloe-medical-group.com/en/aloe-vera/history.html

    What Aloe Vera Does in Your Body: Why Egyptians Called it the Plant of Immortality: Available at: http://www.collective-evolution.com/2016/03/09/what-aloe-vera-does-in-your-body-why-egyptians-called-it-the-plant-of-immortality/

    This is Why Ancient Egyptians Referred to Aloe Vera as the 'Plant of Immortality'. Available at: http://www.naturalnews.com/054275_Aloe_vera_natural_medicine_superfood.html

    Medicinal History of Aloe Vera. Available at: http://www.aloelf.com/aloe-vera/medicinal-history-of-aloe-vera/

    The Benefits of the Ese of Aloe Vera in Herbal Preparations. Available at: http://www.herballegacy.com/Baldwin_History.html

    http://www.ancient-origins.net/history/ancient-plant-immortality-treats-over-50-medical-conditions-007505?nopaging=1

     

     

     

     

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