CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Fasting-Caloric Restriction

Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease. 📎

Written by CYBERMED LIFE NEWS
Attachments:
Download this file (Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease..pdf)Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease..pdf[Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease.]1595 kB
facebook Share on Facebook
Abstract Title:

Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease.

Abstract Source:

Ann Dermatol Venereol. 2006 May;133(5 Pt 1):425-8. PMID: 19320048

Abstract Author(s):

Irina Madorsky, Katherine Opalach, Amanda Waber, Jonathan D Verrier, Chelsea Solmo, Thomas Foster, William A Dunn, Lucia Notterpek

Article Affiliation:

Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

Abstract:

Charcot-Marie-Tooth type 1A (CMT1A) neuropathies linked to the misexpression of peripheral myelin protein 22 (PMP22) are progressive demyelinating disorders of the peripheral nervous system. In this study we asked whether dietary restriction by intermittent fasting (IF) could alleviate the neuropathic phenotype in the Trembler J (TrJ) mouse model of CMT1A. Our results show that neuropathic mice kept on a five month long IF regimen had improved locomotor performance compared to ad libitum (AL) fed littermates. The functional benefits of this dietary intervention are associated with an increased expression of myelin proteins combined with a thicker myelin sheath, less redundant basal lamina, and a reduction in aberrant Schwann cell proliferation. These morphological improvements are accompanied by a decrease in PMP22 protein aggregates, and enhanced expression of cytosolic chaperones and constituents of the autophagy-lysosomal pathway. These results indicate that dietary restriction is beneficial for peripheral nerve function in TrJ neuropathic mice, as it promotes the maintenance of locomotor performance.


We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.