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Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy.
Neurosci Lett. 2006 Apr 24;397(3):219-23. Epub 2006 Jan 6. PMID: 16406309
Department of Anaesthesia, McGill University, Montreal, Que., Canada. This email address is being protected from spambots. You need JavaScript enabled to view it.
This study examines the potential efficacy of acetyl-L-carnitine (ALC) to prevent and treat paclitaxel-induced pain. Rats received four intraperitoneal (i.p.) injections of 2 mg/kg paclitaxel on alternate days which, following a short delay induced marked mechanical hypersensitivity. Daily administration of ALC (50 mg/kg and 100 mg/kg; p.o.; concurrently with paclitaxel and for 14 days afterwards) prevented the development of paclitaxel-induced pain. This effect was long lasting, for at least 3 weeks after the last dose of ALC. In a separate experiment, daily administration of ALC (100 mg/kg; p.o.; for 10 days) to rats with established paclitaxel-induced pain produced an analgesic effect. This effect dissipated shortly after ALC treatment was withdrawn. We conclude that ALC may be useful in the prevention and treatment of chemotherapy-induced painful peripheral neuropathy.