CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Acai

  • Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction📎

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    Abstract Title:

    Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction.

    Abstract Source:

    PLoS One. 2018 ;13(6):e0199207. Epub 2018 Jun 19. PMID: 29920546

    Abstract Author(s):

    Graziele Freitas de Bem, Cristiane Aguiar Costa, Izabelle Barcellos Santos, Viviane da Silva Cristino Cordeiro, Lenize Costa Reis Marins de Carvalho, Marcelo Augusto Vieira de Souza, Ricardo de Andrade Soares, Pergentino José da Cunha Sousa, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura

    Article Affiliation:

    Graziele Freitas de Bem

    Abstract:

    A growing body of evidence suggests a protective role of polyphenols and exercise training on the disorders of type 2 diabetes mellitus (T2DM). We aimed to assess the effect of the açaí seed extract (ASE) associated with exercise training on diabetic complications induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type 2 diabetes was induced by feeding rats with HF diet (55% fat) for 5 weeks and a single dose of STZ (35 mg/kg i.p.). Control (C) and Diabetic (D)animals were subdivided into four groups each: Sedentary, Training, ASE Sedentary, and ASE Training. ASE (200 mg/kg/day) was administered by gavage and the exercise training was performed on a treadmill (30min/day; 5 days/week) for 4 weeks after the diabetes induction. In type 2 diabetic rats, the treatment with ASE reduced blood glucose, insulin resistance, leptin and IL-6 levels, lipid profile, and vascular dysfunction. ASE increased the expression of insulin signaling proteins in skeletal muscle and adipose tissue and plasma GLP-1 levels. ASE associated with exercise training potentiated the reduction of glycemia by decreasing TNF-α levels, increasing pAKT and adiponectin expressions in adipose tissue, and IR and pAMPK expressions in skeletal muscle of type 2 diabetic rats. In conclusion, ASE treatment has an antidiabetic effect in type 2 diabetic rats by activating the insulin-signaling pathway in muscle and adipose tissue, increasing GLP-1 levels, and an anti-inflammatory action. Exercise training potentiates the glucose-lowering effect of ASE by activating adiponectin-AMPK pathway and increasing IR expression.

  • Photodynamic therapy mediated by acai oil (Euterpe oleracea Martius) in nanoemulsion: A potential treatment for melanoma.

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    Abstract Title:

    Photodynamic therapy mediated by acai oil (Euterpe oleracea Martius) in nanoemulsion: A potential treatment for melanoma.

    Abstract Source:

    J Photochem Photobiol B. 2017 Jan ;166:301-310. Epub 2016 Dec 9. PMID: 28024281

    Abstract Author(s):

    Victoria Monge-Fuentes, Luis Alexandre Muehlmann, João Paulo Figueiró Longo, Jaqueline Rodrigues Silva, Maria Luiza Fascineli, Paulo de Souza, Fernando Faria, Igor Anatolievich Degterev, Anselmo Rodriguez, Fabiana Pirani Carneiro, Carolina Madeira Lucci, Patricia Escobar, Rivadávio Fernandes Batista Amorim, Ricardo Bentes Azevedo

    Article Affiliation:

    Victoria Monge-Fuentes

    Abstract:

    Melanoma is the most aggressive and lethal form of skin cancer, responsible for>80% of deaths. Standard treatments for late-stage melanoma usually present poor results, leading to life-threatening side effects and low overall survival. Thus, it is necessary to rethink treatment strategies and design new tools for the treatment of this disease. On that ground, we hereby report the use of acai oil in nanoemulsion (NanoA) as a novel photosensitizer for photodynamic therapy (PDT) used to treat melanoma in in vitro and in vivo experimental models. NIH/3T3 normal cells and B16F10 melanoma cell lines were treated with PDT and presented 85% cell death for melanoma cells, while maintaining high viability in normal cells. Flow cytometry indicated that cell death occurred by late apoptosis/necrosis. Tumor bearing C57BL/6 mice treated five times with PDT using acai oil in nanoemulsion showed tumor volume reduction of 82% in comparison to control/tumor group. Necrotic tissue per tumor area reached its highest value in PDT-treated mice, supporting PDT efficacy. Overall, acai oil in nanoemulsion was an effective photosensitizer, representing a promising source of new photosensitizing molecules for PDT treatment of melanoma, a tumor with an inherent tendency to be refractory for this type of therapy.

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