Abstract Title:
Chronic anterior uveitis following bacille Calmette-Guérin vaccination: molecular mimicry in action?
Abstract Source:
J Pediatr Ophthalmol Strabismus. 2008 Jul-Aug;45(4):252-3. PMID: 18705627
Article Affiliation:
Alexander Spratt
Abstract:
A 13-year-old girl developed bilateral chronic anterior uveitis following bacille Calmette-Guérin (BCG) vaccination. HLA testing was negative for B27 but positive for DRB1 *0404, a variant of DR4 often associated with rheumatoid arthritis. The authors propose her HLA repertoire allowed for a BCG-induced abnormal autoimmune response by the mechanism of molecular mimicry.
Article Published Date : Jun 30, 2008