Interleukin-33 promotes helper T cell type-2/17 inflammation in children with allergic rhinitis.
Eur Arch Otorhinolaryngol. 2017 Nov 17;:
Authors: Wang Y, Li C, Luo X, Xu D, Xu Y, Li G, Liao F, Tan S
OBJECTIVES: Interleukin-33 is a recently described cytokine which involved in helper T cell type-2 (Th2) mediated diseases. However, its regulatory effect in the pathogenesis of children allergic rhinitis (AR) needs to be further characterized. This study aims to evaluate the expression and role of IL-33 in children with AR.
METHODS: Forty children with AR and twenty normal controls were included. IL-33 and Th cytokine production in serum and nasal lavage was examined by immunosorbent assay (ELISA), respectively. Peripheral blood mononuclear cells (PBMCs) were purified for in vitro regulation experiment of IL-33.
RESULTS: The IL-33 protein levels in both serum and nasal lavage were significantly enhanced in AR compared with normal controls, especially in children with asthma. The IL-33 protein expression was correlated to severity of disease. In vitro study showed that IL-33 promotes Th2/17 cytokine expression and thus amplified Th2/17 inflammation.
CONCLUSIONS: Our results demonstrate that IL-33 expression in AR aggravated and amplified Th2/17 inflammation, and provide a possible explanation for IL-33's regulatory role in the pathogenesis of AR.
PMID: 29150715 [PubMed - as supplied by publisher]