CYBERMED LIFE - ORGANIC  & NATURAL LIVING

Cybermedlife - Therapeutic Actions Chelation Therapy EDTA

Efficacy of Chelation Therapy to Remove Aluminium Intoxication

Abstract Title: Efficacy of Chelation Therapy to Remove Aluminium Intoxication Abstract Source: https://pubmed.ncbi.nlm.nih.gov/26404567/?from_term=cellfood&from_pos=5 Abstract Author(s): Alessandro Fulgenzi , Rachele De Giuseppe , Fabrizia Bamonti , Daniele Vietti , Maria Elena Ferrero   Abstract: There is a distinct correlation between aluminium (Al) intoxication and neurodegenerative diseases (ND). We demonstrated how patients affected by ND showing Al intoxication benefit from short-term treatment with calcium disodium ethylene diamine tetraacetic acid (EDTA) (chelation therapy). Such therapy further improved through daily treatment with the antioxidant Cellfood. In the present study we examined the efficacy of long-term treatment, using both EDTA and Cellfood. Slow intravenous treatment with the chelating agent EDTA (2 g/10 mL diluted in 500 mL physiological saline administered in 2 h) (chelation test) removed Al, which was detected (using inductively coupled plasma mass spectrometry) in urine samples collected from patients over 12 h. Patients that revealed Al intoxication (expressed in μg per g creatinine) underwent EDTA chelation therapy once a week for ten weeks, then once every two weeks for a further six or twelve months. At the end of treatment (a total of 22 or 34 chelation therapies, respectively), associated with daily assumption of Cellfood, Al levels in the urine samples were analysed. In addition, the following blood parameters were determined: homocysteine, vitamin B12, and folate, as well as the oxidative status e.g. reactive oxygen species (ROS), total antioxidant capacity (TAC), oxidized LDL (oxLDL), and glutathione. Our results showed that Al intoxication reduced significantly following EDTA and Cellfood treatment, and clinical symptoms improved. After treatment, ROS, oxLDL, and homocysteine decreased significantly, whereas vitamin B12, folate and TAC improved significantly. In conclusion, our data show the efficacy of chelation therapy associated with Cellfood in subjects affected by Al intoxication who have developed ND. Article Published Date : Set 24, 2015

Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxication.

Abstract Title: Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxication. Abstract Source: Hum Exp Toxicol. 2010 Apr 22. Epub 2010 Apr 22. PMID: 20413561 Abstract Author(s): Hyo-wook Gil, Eun-jung Kang, Kwon-hyun Lee, Jong-oh Yang, Eun-young Lee, Sae-yong Hong Article Affiliation: Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan City, South Korea. Abstract: In order to evaluate the efficiency and renal protective effects of glutathione during Ca(++)-EDTA chelation therapy for chronic cadmium intoxication, we measured the renal excretion of cadmium, beta2-microglobulin, proteinuria, and hematuria during intravenous administration of glutathione with Ca(++)-EDTA in a 54-year-old patient with chronic cadmium intoxication. We administered 500 mg of Ca(++)-EDTA and 50 mg/kg of glutathione alone or in 1 L of normal saline over the next 24 hours and repeated this over 12 consecutive days. During the first 3 days, the basal levels (only saline administration) were determined; during the second 3 days, Ca(++)-EDTA only was administered, for the third sequence of 3 days, Ca(++)-EDTA with glutathione was provided, and for the last 3 days, glutathione alone was given. One month later, the same protocol was repeated. There were six blood and urine samples to analyze in each group. The blood cadmium level was higher when the EDTA was infused together with glutathione (7.44 +/- 0.73 mug/L, p<0.01) compared to the basal level of 4.6 +/- 0.44 mug/L. Also, the renal cadmium excretion was significantly higher in the EDTA with glutathione group than in the basal group (23.4 +/- 15.81 mug/g creatinine vs 89.23 +/- 58.52 mug/g creatinine, p<0.01). There was no difference in the protein/creatinine and beta2-microglobulin/creatinine ratio in the urine (p>0.05) among the groups. Furthermore, microhematuria and proteinuria did not develop over the observation period of 6 months. These results suggest that glutathione administration with EDTA might be an effective treatment modality for patients with cadmium intoxication. Article Published Date : Apr 22, 2010

The usefulness of chelation therapy for the remission of symptoms caused by previous treatment with mercury-containing pharmaceuticals: a case report📎

Abstract Title: The usefulness of chelation therapy for the remission of symptoms caused by previous treatment with mercury-containing pharmaceuticals: a case report. Abstract Source: Cases J. 2009 Nov 18;2:199. PMID: 19946446 Abstract Author(s): Serafina Corsello, Alessandro Fulgenzi, Daniele Vietti, Maria Elena Ferrero Abstract: INTRODUCTION: A great deal of data regarding the toxicology of mercury has been recently reported. Although the most common human exposures to mercury are currently mercury vapour from amalgam tooth fillings, methylmercury from seafood and ethylmercury as a preservative in vaccines, in the past mercury compounds have been used in the treatment of syphilis. CASE PRESENTATION: Mercury intoxication was found in a 67 year-old Italian man affected by neurological symptoms of apparently unknown origin. The patient developed syphilis forty years ago and then underwent therapy with mercurials to treat his chronic bacterial infection. We treated the patient with disodium edetate chelation therapy. Six months after the beginning of the therapy, the patient's neurological symptoms began to decrease, and were completely cured after two years of therapy. CONCLUSION: This case supports the use of chelation therapy with disodium edetate to remove damages caused by mercury intoxication. Article Published Date : Nov 18, 2009

EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation📎

Abstract Title: EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation. Abstract Source: Altern Med Rev. 2009 Mar;14(1):56-61. PMID: 19364193 Abstract Author(s): Anne Marie Roussel, Isabelle Hininger-Favier, Robert S Waters, Mireille Osman, Karen Fernholz, Richard A Anderson Abstract: Chelation therapy is thought to not only remove contaminating metals but also to decrease free radical production. However, in standard ethylene diamine tetracetic acid (EDTA) chelation therapy, high doses of vitamin C with potential pro-oxidant effects are often added to the chelation solution. The authors demonstrated previously that the intravenous administration of the standard chelation cocktail, containing high amounts of vitamin C, resulted in an acute transitory pro-oxidant burst that should be avoided in the treatment of pathologies at risk of increased oxidative stress such as diabetes and cardiovascular disease. The current study was designed to determine the acute and chronic biochemical effects of chelation therapy on accepted clinical, antioxidant variables. An EDTA chelation cocktail not containing ascorbic acid was administered to six adult patients for five weeks (10 sessions of chelation therapy); antioxidant indicators were monitored. Immediately after the initial chelation session, in contrast with the data previously reported with the standard cocktail containing high doses of vitamin C, none of the oxidative stress markers were adversely modified. After five weeks, plasma peroxide levels, monitored by malondialdehyde, decreased by 20 percent, and DNA damage, monitored by formamidopyrimidine-DNA glycosylase (Fpg) sensitive sites, decreased by 22 percent. Remaining antioxidant-related variables did not change. In summary, this study demonstrates that multiple sessions of EDTA chelation therapy in combination with vitamins and minerals, but without added ascorbic acid, decreases oxidative stress. These results should be beneficial in the treatment of diseases associated with increased oxidative stress such as diabetes and cardiovascular diseases. Article Published Date : Mar 01, 2009

Effectiveness of treatment of calcific tendinitis of the shoulder by disodium EDTA📎

Abstract Title: Effectiveness of treatment of calcific tendinitis of the shoulder by disodium EDTA. Abstract Source: Arthritis Rheum. 2009 Jan 15;61(1):84-91. PMID: 19116968 Abstract Author(s): Angelo Cacchio, Elisabetta De Blasis, Piergiorgio Desiati, Giorgio Spacca, Valter Santilli, Fosco De Paulis Article Affiliation: San Salvatore Hospital of L'Aquila, Via L. Natali 1, 67100 L'Aquila, Italy. This email address is being protected from spambots. You need JavaScript enabled to view it. Abstract: OBJECTIVE: To evaluate the effectiveness of disodium EDTA administration in the treatment of calcific tendinitis of the shoulder. METHODS: Eighty patients with radiographically verified calcific tendinitis of the shoulder were enrolled between September 2001 and October 2003. Patients were randomly assigned to either a study group (n = 40) or a control group (n = 40). Pain and functional level were evaluated before and after treatment and at 1-year followup. Radiographic modifications in calcifications were evaluated before and after treatment. Disodium EDTA was administered through single needle mesotherapy and 15 minutes of pulsed-mode 1 MHz-ultrasound. RESULTS: The study group displayed improvement in all of the parameters analyzed after treatment and at the 1-year followup. Calcifications disappeared completely in 62.5% of the patients in the study group and partially in 22.5%; calcifications partially disappeared in only 15% of the patients in the control group, and none displayed a complete disappearance. CONCLUSION: Our results suggest that the use of disodium EDTA for the management of calcific tendinitis of the shoulder is safe and effective, leading to a significant reduction in pain, improvement in shoulder function, and disappearance of calcifications after 4 weeks, without adverse effects. Article Published Date : Jan 15, 2009
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